Emerging role of immune cells as drivers of pulmonary fibrosis

SE Mutsaers, T Miles, CM Prêle, GF Hoyne - Pharmacology & Therapeutics, 2023 - Elsevier
The pathogenesis of pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF) and
other forms of interstitial lung disease, involves a complex interplay of various factors …

[HTML][HTML] Idiopathic pulmonary fibrosis and lung cancer: future directions and challenges

AA Qubo, J Numan, J Snijder, M Padilla… - …, 2023 - publications.ersnet.org
Idiopathic pulmonary fibrosis (IPF) is a progressive disease of pulmonary scarring. New
treatments slow disease progression and allow pulmonary fibrosis patients to live longer …

Expression of PD-1/PD-L1 axis in mediastinal lymph nodes and lung tissue of human and experimental lung fibrosis indicates a potential therapeutic target for …

T Karampitsakos, A Galaris, S Chrysikos… - Respiratory …, 2023 - Springer
Background Mediastinal lymph node enlargement is prevalent in patients with idiopathic
pulmonary fibrosis (IPF). Studies investigating whether this phenomenon reflects specific …

PD-1/PD-L1 axis in organ fibrosis

Y Zhao, Y Qu, C Hao, W Yao - Frontiers in immunology, 2023 - frontiersin.org
Fibrosis is a pathological tissue repair activity in which many myofibroblasts are activated
and extracellular matrix are excessively accumulated, leading to the formation of permanent …

Mesenchymal cells in the Lung: Evolving concepts and their role in fibrosis

G Ligresti, AA Raslan, J Hong, N Caporarello… - Gene, 2023 - Elsevier
Mesenchymal cells in the lung are crucial during development, but also contribute to the
pathogenesis of fibrotic disorders, including idiopathic pulmonary fibrosis (IPF), the most …

The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases

A Salminen - Journal of Molecular Medicine, 2024 - Springer
The accumulation of senescent cells within tissues is a hallmark of the aging process.
Senescent cells are also commonly present in many age-related diseases and in the cancer …

Management of patients with idiopathic pulmonary fibrosis and lung cancer: challenges in clinical practice

T Karampitsakos, F Sampsonas… - Current Opinion in …, 2023 - journals.lww.com
Management of patients with idiopathic pulmonary fibrosis an... : Current Opinion in Pulmonary
Medicine Management of patients with idiopathic pulmonary fibrosis and lung cancer …

The role of PD-1/PD-L1 axis in idiopathic pulmonary fibrosis: Friend or foe?

A Jiang, N Liu, J Wang, X Zheng, M Ren… - Frontiers in …, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease with a bleak
prognosis. Mounting evidence suggests that IPF shares bio-molecular similarities with lung …

[HTML][HTML] Highlights on future treatments of IPF: clues and pitfalls

A Libra, E Sciacca, G Muscato, G Sambataro… - International Journal of …, 2024 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by irreversible
scarring of lung tissue, leading to death. Despite recent advancements in understanding its …

Injury activated alveolar progenitors (IAAPs): the underdog of lung repair

L Chong, N Ahmadvand, A Noori, Y Lv, C Chen… - Cellular and Molecular …, 2023 - Springer
Alveolar epithelial type II cells (AT2s) together with AT1s constitute the epithelial lining of
lung alveoli. In contrast to the large flat AT1s, AT2s are cuboidal and smaller. In addition to …