Researchers' increasing awareness of the essential role played by RNA in many biological
processes and in the progression of disease makes the discovery of new RNA targets an …

Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a
profound effect on all branches of chemistry, but especially on drug discovery. This …

The interaction of the HIV-1 transactivator protein Tat with its transactivation response (TAR)
RNA is an essential step in viral replication and therefore an attractive target for developing …

Phenothiazines were identified by virtual screening as promising ligands for HIV-1 TAR RNA
and A-site ribosomal RNA, and binding in each case was verified experimentally …

The targeting of RNA for the design of novel anti-viral compounds represents an area of vast
potential. We have used NMR and computational methods to model the interaction of a …

Small molecule ligand–RNA interactions have the potential to influence gene expression at
a variety of steps and in a number of ways. Here, we demonstrate that such interactions are …

A series of neomycin dimers have been synthesized using “click chemistry” with varying
functionality and length in the linker region to target the human immunodeficiency virus type …

Antiretroviral therapy to treat AIDS uses molecules that target the reverse transcriptase and
protease enzymes of human immunodeficiency virus, type 1 (HIV-1). A major problem …

Historically, pharmaceutical industries have focussed on the discovery of compounds that
target the protein products of genes. The intermediary product between gene and protein …

The rapidly expanding database of RNA structures and protein complexes is beginning to
lead to the successful design of specific RNA-binding molecules. Recent combinatorial and …