Increased interest in the pathogenic potential of Yersinia pestis has emerged because of the
potential threats from bioterrorism. Pathogenic potential is based on genetic factors present …

Beyond the innate response that is elicited when tissues are infected, bacterial pathogens
have evolved strategies to subvert the immune response and" recalibrate" it both …

Pseudomonas aeruginosa is an opportunistic bacterial pathogen that can cause fatal acute
lung infections in critically ill individuals. Damage to the lung epithelium is associated with …

The plague is caused by the bacterium Yersinia pestis. Plague bacteria are thought to inject
effector Yop proteins into host cells via the type III pathway. The identity of the host cells …

Background Bacteriophages specific for Yersinia pestis are routinely used for plague
diagnostics and could be an alternative to antibiotics in case of drug-resistant plague. A …

The current human whole-cell vaccine is ineffective against pneumonic plague caused by
typical F1 capsule positive (F1+) strains of Yersinia pestis. The authors found this vaccine to …

Subunit vaccine discovery is an accepted clinical priority. The empirical approach is time-
and labor-consuming and can often end in failure. Rational information-driven approaches …

Type III‐mediated translocation of Yop effectors is an essential virulence mechanism of
pathogenic YersiniaLcrV is the only protein secreted by the type III secretion system that …

Yersinia pestis is the etiological agent of bubonic and pneumonic plague, diseases which
have caused over 200 milllion human deaths in the past. Plague still occurs throughout the …

Pseudomonas aeruginosa is a gram-negative pathogen causing life-threatening infections.
Lung injury and the development of sepsis depend largely on the expression of type III …