Calcium (Ca2+) functions as a second messenger that is critical in regulating fundamental
physiological functions such as cell growth/development, cell survival, neuronal …

Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …

The outbreak of COVID-19 caused by SARS-CoV-2 has resulted in more than 50 million
confirmed cases and over 1 million deaths worldwide as of November 2020. Currently, there …

Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major
component of fibrillar alpha‐synuclein (α‐syn). Herein, boosting PD therapeutic efficacy by …

Macroautophagy is a lysosomal degradative pathway or recycling process that maintains
cellular homeostasis. This autophagy involves a series of sequential processing events …

Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central
nervous system (CNS) due to an increase of abnormal peripherally auto-reactive T …

Matrine (MT) is a naturally occurring alkaloid and an bioactive component of Chinese herbs,
such as Sophora flavescens and Radix Sophorae tonkinensis. Emerging evidence suggests …

The neuropathological features of Alzheimer's disease include amyloid plaques. Rapidly
emerging evidence suggests that Piezo1, a mechanosensitive cation channel, plays a …

The regulation of reactive oxygen species (ROS)-sensitive calcium (Ca2+) channels is of
great significance in the treatment of tumors. Here, a simple ROS generation system is …

ABSTRACT PSEN2 (presenilin 2) is one of the 3 proteins that, when mutated, causes early
onset familial Alzheimer disease (FAD) cases. In addition to its well-known role within the γ …