The majority of the thiols (SH) 2 and disulfides (SS) in cells are found as the amino acid
cysteine and its disulfide, cystine (Fig. 1 A). The thiolate anion is intrinsically one of the …

The regulation of divalent zinc has been observed in a wide range of organisms. Since this
metal is an essential nutrient, but also toxic in excess, zinc homeostasis is crucial for normal …

The solution and complexation chemistry of zinc ions is the basis for zinc biology. In living
organisms, zinc is redox-inert and has only one valence state: Zn (II). Its coordination …

A linear correlation between pH-meter readings in equivalent D2O and H2O solutions,
determined experimentally, leads to a novel equation, which allows for a direct recalculation …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Asthma is an intractable disease involving the infiltration of inflammatory cells and mucus
plugging. Despite small molecular mucolytics having the ability to break the disulfide bonds …

Each of the seven Zn (II) ions in the Zn3S9 and Zn4S11 clusters of human metallothionein is
in a tetrathiolate coordination environment. Yet analysis of Zn (II) association with thionein …

Tris (2-carboxyethyl) phosphine (TCEP) is a widely used substitute for dithiothreitol (DTT) in
the reduction of disulfide bonds in biochemical systems. Although TCEP has been recently …

Mammalian metallothioneins (MTs) are small cysteine-rich proteins whose primary role is
participation in zinc and copper homeostasis. Ever since their discovery, MTs have been …

Small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS) are
techniques used to extract structural parameters and determine the overall structures and …