Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics
JJ Rennick, APR Johnston, RG Parton - Nature nanotechnology, 2021 - nature.com
Endocytosis is a critical step in the process by which many therapeutic nanomedicines reach
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …
Endocytosis in cancer and cancer therapy
Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …
Mechanisms for regulating and organizing receptor signaling by endocytosis
M von Zastrow, A Sorkin - Annual review of biochemistry, 2021 - annualreviews.org
Intricate relationships between endocytosis and cellular signaling, first recognized nearly 40
years ago through the study of tyrosine kinase growth factor receptors, are now known to …
years ago through the study of tyrosine kinase growth factor receptors, are now known to …
[HTML][HTML] Endocytosis inhibition in humans to improve responses to ADCC-mediating antibodies
A safe and controlled manipulation of endocytosis in vivo may have disruptive therapeutic
potential. Here, we demonstrate that the anti-emetic/anti-psychotic prochlorperazine can be …
potential. Here, we demonstrate that the anti-emetic/anti-psychotic prochlorperazine can be …
Insulin-like growth factor 2 (IGF2)-fused lysosomal targeting chimeras for degradation of extracellular and membrane proteins
Targeted degradation of the cell-surface and extracellular proteins via the endogenous
lysosomal degradation pathways, such as lysosome-targeting chimeras (LYTACs), has …
lysosomal degradation pathways, such as lysosome-targeting chimeras (LYTACs), has …
[HTML][HTML] Substratum stiffness regulates Erk signaling dynamics through receptor-level control
The EGFR/Erk pathway is triggered by extracellular ligand stimulation, leading to stimulus-
dependent dynamics of pathway activity. Although mechanical properties of the …
dependent dynamics of pathway activity. Although mechanical properties of the …
3D‐Engineered scaffolds to study microtubes and localization of epidermal growth factor receptor in patient‐derived glioma cells
N Barin, HE Balcioglu, I de Heer, M de Wit… - Small, 2022 - Wiley Online Library
A major obstacle in glioma research is the lack of in vitro models that can retain cellular
features of glioma cells in vivo. To overcome this limitation, a 3D‐engineered scaffold …
features of glioma cells in vivo. To overcome this limitation, a 3D‐engineered scaffold …
A live-cell screen for altered Erk dynamics reveals principles of proliferative control
Complex, time-varying responses have been observed widely in cell signaling, but how
specific dynamics are generated or regulated is largely unknown. One major obstacle has …
specific dynamics are generated or regulated is largely unknown. One major obstacle has …
The story of EGFR: from signaling pathways to a potent anticancer target
S Ramani, S Samant, SM Manohar - Future Medicinal Chemistry, 2022 - Taylor & Francis
EGFR is a member of the ERBB family. It plays a significant role in cellular processes such
as growth, survival and differentiation via the activation of various signaling pathways. EGFR …
as growth, survival and differentiation via the activation of various signaling pathways. EGFR …
Endometrial small extracellular vesicles regulate human trophectodermal cell invasion by reprogramming the phosphoproteome landscape
A series of cyclical events within the uterus are crucial for pregnancy establishment. These
include endometrial regeneration following menses, under the influence of estrogen …
include endometrial regeneration following menses, under the influence of estrogen …