Cadmium as a testicular toxicant: A Review

JK Bhardwaj, H Panchal, P Saraf - Journal of Applied …, 2021 - Wiley Online Library
Cadmium (Cd) is a toxic heavy metal with no known biological functions in the human body.
Due to a considerably long biological half‐life and very low rate of excretion, accumulation …

[HTML][HTML] The role of toxic metals and metalloids in Nrf2 signaling

A Buha, K Baralić, D Djukic-Cosic, Z Bulat, A Tinkov… - Antioxidants, 2021 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (Nrf2), an emerging regulator of cellular resistance
to oxidants, serves as one of the key defensive factors against a range of pathological …

Protocatechuic acid mitigates cadmium-induced neurotoxicity in rats: Role of oxidative stress, inflammation and apoptosis

EM Al Olayan, AS Aloufi, OD AlAmri, H Ola… - Science of the total …, 2020 - Elsevier
Environmental and occupational exposure to heavy metals, including cadmium (Cd), is
associated with extremely adverse impacts to living systems. Antioxidant agents are …

Diacerein downregulates NLRP3/Caspase-1/IL-1β and IL-6/STAT3 pathways of inflammation and apoptosis in a rat model of cadmium testicular toxicity

AA Fouad, AM Abdel-Aziz, AAH Hamouda - Biological Trace Element …, 2020 - Springer
The potential gonadal protective effect of diacerein (DCN) and its underlying mechanisms
were studied in a rat model of cadmium-induced testicular toxicity. The rats received DCN …

Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage

X Li, Z Yao, D Yang, X Jiang, J Sun, L Tian, J Hu… - Journal of hazardous …, 2020 - Elsevier
Cadmium (Cd) is an environmental contaminant found in soil, water, and food, and can
cause oxidative stress and male reproductive damage. During puberty, the male …

Ferulic acid influences Nrf2 activation to restore testicular tissue from cadmium‐induced oxidative challenge, inflammation, and apoptosis in rats

RB Kassab, MS Lokman, HMA Daabo… - Journal of food …, 2020 - Wiley Online Library
Here, we examined the protective effect of ferulic acid (FA) on cadmium chloride (CdCl2)‐
mediated reproductive toxicity in male rats. Animals were divided into four groups: control …

Discovery of a potent glutathione peroxidase 4 inhibitor as a selective ferroptosis inducer

C Xu, Z Xiao, J Wang, H Lai, T Zhang… - Journal of Medicinal …, 2021 - ACS Publications
Potent and selective ferroptosis regulators promote an intensive understanding of the
regulation and mechanisms underlying ferroptosis, which is highly associated with various …

[HTML][HTML] A flavonoid-rich extract from bergamot juice, alone or in association with curcumin and resveratrol, shows protective effects in a murine model of cadmium …

N Ferlazzo, A Micali, HR Marini, J Freni, G Santoro… - Pharmaceuticals, 2021 - mdpi.com
It is known that cadmium damages testis structure and functionality. We examined the effects
of nutraceuticals such as a flavonoid-rich extract of bergamot juice (BJe), alone or in …

Luteolin protects against testicular injury induced by lead acetate by activating the Nrf2/HO‐1 pathway

WA AL‐Megrin, S Alomar, AF Alkhuriji… - IUBMB …, 2020 - Wiley Online Library
Lead (Pb) is a toxic heavy metal that is harmful to humans, especially male reproductive
organs. Luteolin (LUT) is a naturally occurring flavonoid with numerous biological activities …

Senna alexandrina extract supplementation reverses hepatic oxidative, inflammatory, and apoptotic effects of cadmium chloride administration in rats

X Wang, T Wang, T Pan, M Huang, W Ren, G Xu… - … Science and Pollution …, 2020 - Springer
Senna alexandrina is traditionally used for its antioxidant and anti-inflammatory properties,
but little information is available concerning its potential protective effects against cadmium …