Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Protein ubiquitination has become one of the most extensively studied post-translational
modifications. Originally discovered as a critical element in highly regulated proteolysis …

This study was conducted to estimate the protective effect of Cyanidin‐3‐glucoside (C3G) on
myocardial ischemia‐reperfusion (IR) injury and to explore its mechanism. The rats were …

Ubiquitination/ubiquitylation, one of the most fundamental post-translational modifications,
regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown …

Abstract Background Cancer-associated fibroblasts (CAFs), the predominant stromal cell of
tumor microenvironment (TME), play an important role in tumor progression and …

Gastrointestinal (GI) cancers with a high incidence rate and adverse complications are
associated with severe morbidity and mortality around the world. It is well recognized that …

Autophagy is a fundamental biological process critical to all eukaryotic cellular life. Although
autophagy has been increasingly studied, how its process is precisely coordinated remains …

The difficulty of early diagnosis and the development of drug resistance are two major
barriers to the successful treatment of cancer. Autophagy plays a crucial role in several …

Ferroptosis is an iron-dependent type of regulated cell death resulting from extensive lipid
peroxidation and plays a critical role in various physiological and pathological processes …

Non-small cell lung cancers (NSCLC) frequently contain KRAS mutation but retain wild-type
TP53. Abundant senescent cells are observed in premalignant but not in malignant tumors …