γδ T-cells directly recognize and kill transformed cells independently of HLA-antigen
presentation, which makes them a highly promising effector cell compartment for cancer …

Abstract γδ T cells play uniquely important roles in stress surveillance and immunity for
infections and carcinogenesis. Human γδ T cells recognize and kill transformed cells …

In normal individuals, γδ T cells account for less than 6% of total peripheral T lymphocytes
and mainly express T-cell receptor (TCR) Vδ2-Vγ9 chains. We have previously observed a …

The tumor immune microenvironment contributes to tumor initiation, progression, and
response to therapy. Among the immune cell subsets that play a role in the tumor …

Apart from their activity in combating infections, neutrophils play an important role in
regulating the tumor microenvironment. Neutrophils can directly kill (antibody-coated) …

The fetus and infant are highly susceptible to viral infections. Several viruses, including
human cytomegalovirus (CMV), cause more severe disease in early life compared with later …

Cancer immunotherapy is a field of interest in the recent treatment approaches against
cancer cells, as it could use the assets of the host's immune system against the invading …

Abstract Bacillus Calmette–Guérin vaccine is well known for inducing trained immunity in
myeloid and natural killer cells, which can explain its cross-protective effect against …

On the path to successful immunotherapy of hematopoietic tumors, γδ T cells offer great
promise because of their human leukocyte antigen (HLA)–unrestricted targeting of a wide …

Recent findings in the immunology field have pointed out the emergent role of butyrophilins/
butyrophilin-like molecules (BTN/BTNL in human, Btn/Btnl in mouse) in the modulation of γδ …