Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …

The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …

Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …

The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …

Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of
inflammation in diverse physiological and pathological contexts. Although the role of …

Simple Summary A fundamental feature of cellular senescence is the emergence of the
Senescence-Associated Secretory Phenotype (SASP), which represents a considerable …

Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …

The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
exert essential regulatory function in microbial-and onco-immunology through the induction …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …