Chronic pain caused by injury or disease of the nervous system (neuropathic pain) has been
linked to persistent electrical hyperactivity of the sensory neurons (nociceptors) specialized …

Interferons (IFNs) are pleiotropic cytokines originally identified for their antiviral activity. IFN-
α and IFN-β are both type I IFNs that have been used to treat neurological diseases such as …

Sensory neurons of the dorsal root ganglion (DRG) are critical for maintaining tissue
homeostasis by sensing and initiating responses to stimuli. While most preclinical studies of …

Classical migraine patients experience aura, which is transient neurological deficits
associated with cortical spreading depression (CSD), preceding headache attacks. It is not …

The versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG)
neurons. However, soma transcriptomes of individual human (h) DRG neurons—critical …

Sensory neurons in the dorsal root ganglion (DRG) and trigeminal ganglion (TG) are
specialized to detect and transduce diverse environmental stimuli to the central nervous …

There are several endogenous molecules that can trigger migraine attacks when
administered to humans. Notably, calcitonin gene-related peptide (CGRP) has been …

Mesenchymal stem cells (MSCs) reside in microenvironments, referred to as niches, which
provide structural support and molecular signals. Sensory nerves are niche components in …

Dental primary afferent (DPA) neurons and proprioceptive mesencephalic trigeminal
nucleus (MTN) neurons, located in the trigeminal ganglion and the brainstem, respectively …

Single-cell RNA sequencing (scRNA-seq) has allowed profiling cell types of the dorsal root
ganglia (DRG) and their transcriptional states in physiology and chronic pain. However, the …