RNA-binding proteins in the regulation of adipogenesis and adipose function

P Zhang, W Wu, C Ma, C Du, Y Huang, H Xu, C Li… - Cells, 2022 - mdpi.com
The obesity epidemic represents a critical public health issue worldwide, as it is a vital risk
factor for many diseases, including type 2 diabetes (T2D) and cardiovascular disease …

RNA binding proteins in senescence: a potential common linker for age-related diseases?

A Varesi, LIM Campagnoli, A Barbieri, L Rossi… - Ageing Research …, 2023 - Elsevier
Aging represents the major risk factor for the onset and/or progression of various disorders
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …

Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis

H Takada, Y Sasagawa, M Yoshimura… - Nature …, 2023 - nature.com
Defects in gastric progenitor cell differentiation are associated with various gastric disorders,
including atrophic gastritis, intestinal metaplasia, and gastric cancer. However, the …

The RNA-binding protein HuR is a negative regulator in adipogenesis

DTC Siang, YC Lim, AMM Kyaw, KN Win… - Nature …, 2020 - nature.com
Human antigen R (HuR) is an essential regulator of RNA metabolism, but its function in
metabolism remains unclear. This study identifies HuR as a major repressor during …

mRNA m5C inhibits adipogenesis and promotes myogenesis by respectively facilitating YBX2 and SMO mRNA export in ALYREF-m5C manner

Y Liu, Y Yang, R Wu, C Gao, X Liao, X Han… - Cellular and Molecular …, 2022 - Springer
Abstract Although 5-methylcytosine (m5C) has been identified as a novel and abundant
mRNA modification and associated with energy metabolism, its regulation function in …

RNA‐binding protein YBX1 promotes brown adipogenesis and thermogenesis via PINK1/PRKN‐mediated mitophagy

R Wu, S Cao, F Li, S Feng, G Shu, L Wang… - The FASEB …, 2022 - Wiley Online Library
Promoting the thermogenic function of brown adipose tissue (BAT) is a promising strategy to
combat obesity and metabolic disorders. While much is known about the transcriptional …

The RNA-binding protein RBM47 inhibits non-small cell lung carcinoma metastasis through modulation of AXIN1 mRNA stability and Wnt/β-catentin signaling

D Shen, Y Jiang, J Li, L Xu, K Tao - Surgical Oncology, 2020 - Elsevier
Background Non-small-cell lung cancer (NSCLC) remains a highly prevalent and deadly
form of cancer, with efforts to better understand the molecular basis of the progression of this …

[HTML][HTML] PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA

Y Zhang, Z Song, R Wu, X Kong, H Zhang, S Li, X Gong… - Cell Reports, 2024 - cell.com
Oligodendrocyte progenitor cells (OPCs) differentiate into myelin-producing cells and
modulate neuronal activity. Defects in OPC development are associated with neurological …

Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A

J Cannavino, M Shao, YA An… - Proceedings of the …, 2021 - National Acad Sciences
Homeothermic vertebrates produce heat in cold environments through thermogenesis, in
which brown adipose tissue (BAT) increases mitochondrial oxidation along with uncoupling …

NOVA1 acts as an oncogene in melanoma via regulating FOXO3a expression

X Yu, H Zheng, MTV Chan… - Journal of Cellular and …, 2018 - Wiley Online Library
Increasing studies have suggested that dysregulation of RNA‐binding proteins (RBPs)
contributes to cancer progression. Neuro‐oncological ventral antigen 1 (NOVA1) is a novel …