Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent
death that did not trigger an immune response, in recent years a new concept of …

Research conducted during the past 30 years has increased our understanding of the
mechanisms involved in colorectal cancer initiation and development. The findings have …

REVIEW Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell
suicide program critical for development, tissue homeostasis, and protection against …

Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …

Colorectal cancer (CRC) results from the progressive accumulation of genetic and
epigenetic alterations that lead to the transformation of normal colonic mucosa to …

Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as
microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers …

Each day, approximately 50 to 70 billion cells perish in the average adult because of
programmed cell death (PCD). Cell death in self-renewing tissues, such as the skin, gut, and …

The current understanding of familial colorectal cancer was limited to descriptions of affected
pedigrees until the early 1990s. A series of landscape‐altering discoveries revealed that …

Deregulation of Bcl2 family members is a frequent feature of human malignant diseases and
causal for therapy resistance. A number of studies have recently shed light onto the role of …

DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-
frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within …