Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer's disease
For the past several years, dementia, is one of the predominantly observed groups of
symptoms in a geriatric population. Alzheimer's disease (AD) is a progressive memory …
symptoms in a geriatric population. Alzheimer's disease (AD) is a progressive memory …
Cannabidiol for the treatment of brain disorders: therapeutic potential and routes of administration
The use of cannabidiol (CBD) for treating brain disorders has gained increasing interest.
While the mechanism of action of CBD in these conditions is still under investigation, CBD …
While the mechanism of action of CBD in these conditions is still under investigation, CBD …
Formulation, characterization, and evaluation of β-Cyclodextrin functionalized hypericin loaded nanocarriers
St. John's wort in western Europe has been extensively utilized for the treatment of mild to
moderate depression. Hypericin, a red pigment, is found to be responsible for its …
moderate depression. Hypericin, a red pigment, is found to be responsible for its …
CSF-derived extracellular vesicles from patients with Parkinson's disease induce symptoms and pathology
Parkinson's disease is characterized by the gradual appearance of intraneuronal inclusions
that are primarily composed of misfolded α-synuclein protein, leading to cytotoxicity and …
that are primarily composed of misfolded α-synuclein protein, leading to cytotoxicity and …
Role of particle size in translational research of nanomedicines for successful drug delivery: Discrepancies and inadequacies
Despite significant research progress in substantiating the therapeutic merits of
nanomedicines and the emergence of sophisticated nanotechnologies, the translation of this …
nanomedicines and the emergence of sophisticated nanotechnologies, the translation of this …
Nonviral nanoparticle gene delivery into the CNS for neurological disorders and brain cancer applications
Nonviral nanoparticles have emerged as an attractive alternative to viral vectors for gene
therapy applications, utilizing a range of lipid‐based, polymeric, and inorganic materials …
therapy applications, utilizing a range of lipid‐based, polymeric, and inorganic materials …
Intranasal peptide therapeutics: a promising avenue for overcoming the challenges of traditional CNS drug development
M Bose, G Farias Quipildor, ME Ehrlich, SR Salton - Cells, 2022 - mdpi.com
The central nervous system (CNS) has, among all organ systems in the human body, the
highest failure rate of traditional small-molecule drug development, ranging from 80–100 …
highest failure rate of traditional small-molecule drug development, ranging from 80–100 …
The battle of lipid-based nanocarriers against blood-brain barrier: A critical review
KK Abla, MM Mehanna - Journal of Drug Targeting, 2023 - Taylor & Francis
Central nervous system integrity is the state of brain functioning across sensory, cognitive,
emotional-social behaviors, and motor domains, allowing a person to realise his full …
emotional-social behaviors, and motor domains, allowing a person to realise his full …
Using nanotechnology to deliver biomolecules from nose to brain—peptides, proteins, monoclonal antibodies and RNA
ML Borrajo, MJ Alonso - Drug delivery and translational research, 2022 - Springer
There is a growing number of biomolecules, including peptides, proteins, monoclonal
antibodies and RNA, that could be potentially used for the treatment of central nervous …
antibodies and RNA, that could be potentially used for the treatment of central nervous …
Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis
A Mwema, GG Muccioli, A Des Rieux - Journal of Controlled Release, 2023 - Elsevier
Disorders of the central nervous system (CNS), such as multiple sclerosis (MS) represent a
great emotional, financial and social burden. Despite intense efforts, great unmet medical …
great emotional, financial and social burden. Despite intense efforts, great unmet medical …