Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer's disease

R Taliyan, V Kakoty, KC Sarathlal… - Journal of Controlled …, 2022 - Elsevier
For the past several years, dementia, is one of the predominantly observed groups of
symptoms in a geriatric population. Alzheimer's disease (AD) is a progressive memory …

Cannabidiol for the treatment of brain disorders: therapeutic potential and routes of administration

GTY Yau, W Tai, JC Arnold, HK Chan… - Pharmaceutical …, 2023 - Springer
The use of cannabidiol (CBD) for treating brain disorders has gained increasing interest.
While the mechanism of action of CBD in these conditions is still under investigation, CBD …

Formulation, characterization, and evaluation of β-Cyclodextrin functionalized hypericin loaded nanocarriers

MA Waqar, M Zaman, H Hameed, M Jamshaid… - ACS …, 2023 - ACS Publications
St. John's wort in western Europe has been extensively utilized for the treatment of mild to
moderate depression. Hypericin, a red pigment, is found to be responsible for its …

CSF-derived extracellular vesicles from patients with Parkinson's disease induce symptoms and pathology

S Herman, R Djaldetti, B Mollenhauer, D Offen - Brain, 2023 - academic.oup.com
Parkinson's disease is characterized by the gradual appearance of intraneuronal inclusions
that are primarily composed of misfolded α-synuclein protein, leading to cytotoxicity and …

Role of particle size in translational research of nanomedicines for successful drug delivery: Discrepancies and inadequacies

HW Chan, S Chow, X Zhang, PCL Kwok… - Journal of Pharmaceutical …, 2023 - Elsevier
Despite significant research progress in substantiating the therapeutic merits of
nanomedicines and the emergence of sophisticated nanotechnologies, the translation of this …

Nonviral nanoparticle gene delivery into the CNS for neurological disorders and brain cancer applications

J Yang, KM Luly, JJ Green - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
Nonviral nanoparticles have emerged as an attractive alternative to viral vectors for gene
therapy applications, utilizing a range of lipid‐based, polymeric, and inorganic materials …

Intranasal peptide therapeutics: a promising avenue for overcoming the challenges of traditional CNS drug development

M Bose, G Farias Quipildor, ME Ehrlich, SR Salton - Cells, 2022 - mdpi.com
The central nervous system (CNS) has, among all organ systems in the human body, the
highest failure rate of traditional small-molecule drug development, ranging from 80–100 …

The battle of lipid-based nanocarriers against blood-brain barrier: A critical review

KK Abla, MM Mehanna - Journal of Drug Targeting, 2023 - Taylor & Francis
Central nervous system integrity is the state of brain functioning across sensory, cognitive,
emotional-social behaviors, and motor domains, allowing a person to realise his full …

Using nanotechnology to deliver biomolecules from nose to brain—peptides, proteins, monoclonal antibodies and RNA

ML Borrajo, MJ Alonso - Drug delivery and translational research, 2022 - Springer
There is a growing number of biomolecules, including peptides, proteins, monoclonal
antibodies and RNA, that could be potentially used for the treatment of central nervous …

Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis

A Mwema, GG Muccioli, A Des Rieux - Journal of Controlled Release, 2023 - Elsevier
Disorders of the central nervous system (CNS), such as multiple sclerosis (MS) represent a
great emotional, financial and social burden. Despite intense efforts, great unmet medical …