A fundamental concept in immunology is that the innate immune system initiates or instructs
downstream adaptive immune responses. Inflammasomes are central players in innate …

The incidence of autoimmune diseases has been steadily rising. Concomitantly, the
incidence of most infectious diseases has declined. This observation gave rise to the …

Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS of
unknown cause that remains incurable. Inflammasome-associated caspases mediate the …

Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the
loss of dopaminergic neurons in the substantia nigra (SN) and the reduction of dopamine …

Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …

Highlights•Aβ 1− 42-induced NLRP3 inflammasome activation in BV-2 microglia is mediated
through TLR4.•TLR4/NLRP3 signaling plays a critical role in Aβ 1− 42-induced …

Neurodegenerative diseases are characterized by a dysregulated neuro-glial
microenvironment, culminating in functional deficits resulting from neuronal cell death …

Primary progressive multiple sclerosis is a poorly understood disease entity with no specific
prognostic biomarkers and scarce therapeutic options. We aimed to identify disease activity …

Aims Multiple sclerosis (MS) still maintains increasing prevalence and poor prognosis, while
glucagon‐like peptide‐1 receptor (GLP‐1R) agonists show excellent neuroprotective …

NLRP3 (Nod-like receptor protein 3) belongs to the NOD-like receptor family, which is
activated by pathogen and damage-associated signals to form a multimeric protein complex …