The hygiene hypothesis in autoimmunity: the role of pathogens and commensals
JF Bach - Nature Reviews Immunology, 2018 - nature.com
The incidence of autoimmune diseases has been steadily rising. Concomitantly, the
incidence of most infectious diseases has declined. This observation gave rise to the …
incidence of most infectious diseases has declined. This observation gave rise to the …
Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis
BA McKenzie, MK Mamik, LB Saito… - Proceedings of the …, 2018 - National Acad Sciences
Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS of
unknown cause that remains incurable. Inflammasome-associated caspases mediate the …
unknown cause that remains incurable. Inflammasome-associated caspases mediate the …
MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration
E Lee, I Hwang, S Park, S Hong, B Hwang… - Cell Death & …, 2019 - nature.com
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the
loss of dopaminergic neurons in the substantia nigra (SN) and the reduction of dopamine …
loss of dopaminergic neurons in the substantia nigra (SN) and the reduction of dopamine …
NLRP3 inflammasome in neurological diseases, from functions to therapies
L Song, L Pei, S Yao, Y Wu, Y Shang - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …
Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia
Y Liu, Y Dai, Q Li, C Chen, H Chen, Y Song, F Hua… - Neuroscience …, 2020 - Elsevier
Highlights•Aβ 1− 42-induced NLRP3 inflammasome activation in BV-2 microglia is mediated
through TLR4.•TLR4/NLRP3 signaling plays a critical role in Aβ 1− 42-induced …
through TLR4.•TLR4/NLRP3 signaling plays a critical role in Aβ 1− 42-induced …
NLRP3 inflammasome in neurodegenerative disease
FL Anderson, KE Biggs, BE Rankin, MC Havrda - Translational Research, 2023 - Elsevier
Neurodegenerative diseases are characterized by a dysregulated neuro-glial
microenvironment, culminating in functional deficits resulting from neuronal cell death …
microenvironment, culminating in functional deficits resulting from neuronal cell death …
NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients
S Malhotra, C Costa, H Eixarch, CW Keller, L Amman… - Brain, 2020 - academic.oup.com
Primary progressive multiple sclerosis is a poorly understood disease entity with no specific
prognostic biomarkers and scarce therapeutic options. We aimed to identify disease activity …
prognostic biomarkers and scarce therapeutic options. We aimed to identify disease activity …
Liraglutide attenuate central nervous inflammation and demyelination through AMPK and pyroptosis‐related NLRP3 pathway
Aims Multiple sclerosis (MS) still maintains increasing prevalence and poor prognosis, while
glucagon‐like peptide‐1 receptor (GLP‐1R) agonists show excellent neuroprotective …
glucagon‐like peptide‐1 receptor (GLP‐1R) agonists show excellent neuroprotective …
Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases
X Zhang, A Xu, J Lv, Q Zhang, Y Ran, C Wei… - European journal of …, 2020 - Elsevier
NLRP3 (Nod-like receptor protein 3) belongs to the NOD-like receptor family, which is
activated by pathogen and damage-associated signals to form a multimeric protein complex …
activated by pathogen and damage-associated signals to form a multimeric protein complex …