Recent achievements in the synthesis of benzimidazole derivatives

NT Chung, VC Dung, DX Duc - RSC advances, 2023 - pubs.rsc.org
Benzimidazoles are a class of heterocyclic compounds in which a benzene ring is fused to
the 4 and 5 positions of an imidazole ring. Benzimidazole refers to the parent compound …

Benzimidazole scaffold as a versatile biophore in drug discovery: A review.

P Prajapat, M Kumawat, GL Talesara… - Chemistry & Biology …, 2018 - search.ebscohost.com
Heterocyclic molecules are pervasive in several areas of life sciences. These molecules
perform numerous significant functions in nature, medicine, and technology. Nitrogen …

Efficient synthesis and in silico studies of the benzimidazole hybrid scaffold with the quinolinyloxadiazole skeleton with potential α-glucosidase inhibitory …

SS Bharadwaj, B Poojary, SKM Nandish… - ACS …, 2018 - ACS Publications
The current study evaluates antidiabetic, anticoagulant, and antiplatelet activity of novel
benzimidazole-containing quinolinyl oxadiazoles. These derivatives are synthesized and …

Sodium dithionite mediated one-pot, tandem chemoselective reduction/cyclization for the synthesis of pyrrole fused N-heterocycles

JK Laha, S Panday, P Gupta, SR Seth - Green Chemistry, 2023 - pubs.rsc.org
A chemoselective reduction of a nitro group in the presence of an aldehyde or ester group
integrated with another synthetic transformation leading to the expedient synthesis of …

Metal-and Additive-Free Intramolecular Direct Amidation of Ester Functionality within a Nitroarene Framework: Facile Access to Azaheterocycles

P Gupta, S Panday, A Hazra… - … Sustainable Chemistry & …, 2023 - ACS Publications
A novel intramolecular direct amidation of unactivated esters with nitroarenes under a mild,
practical, and scalable synthetic protocol is the subject of this present investigation. The …

Photocatalytic Strategy to Realize N-Debenzylation via Aerobic Oxidation Catalyzed by 4CzIPN

Y Wu, J Kang, H Zhu, M Bi, J Li, Q Meng… - ACS Sustainable …, 2024 - ACS Publications
It is a great challenge to remove the N-benzyl protecting group selectively by photocatalytic
aerobic oxidation because amides or imines are easily formed from the oxidation of N …

Synthesis, crystal structure, Hirshfeld, DFT, molecular docking, dynamics studies, and anti-cancer activity of 1-substituted-2-(4-(diethylamino)-2-hydroxyphenyl)-1H …

D Ganavi, V Kumar, P Akhileshwari, A Prabhu… - Journal of Molecular …, 2024 - Elsevier
In our present work, a novel series of 1-substituted-2–2-(4-(diethylamino)-2-hydroxyphenyl)-
1H-benzo [d] imidazole-5-ethyl carboxylates were synthesized by an efficient “one-pot” nitro …

A Novel Route to 2-Arylquinolines: Reductive Cleavage of 2′-Nitroaryl-∆ 2-isoxazolines

P Kamath, RC Viner, SC Smith, M Lal - Synlett, 2017 - thieme-connect.com
A novel synthetic route for the synthesis of quinolines starting from Δ 2-isoxazolines under
reductive conditions is reported. The reductive cyclization to quinolines is achieved under …

Small molecule inhibitors of the JAK family of kinases

T Koudriakova, KD Kreutter, K Leonard… - US Patent …, 2019 - Google Patents
((1r, 4r)-4-(imidazo [4, 5-d] pyrrolo [2, 3-b] pyridin-1 (6H)-yl) cyclohexyl) acetonitrile
compounds, pharmaceutical compositions containing them, methods of making them, and …

Imidazopyrrolopyridine as inhibitors of the jak family of kinases

GM Bacani, W Chai, T Koudriakova… - US Patent …, 2021 - Google Patents
US10981911B2 - Imidazopyrrolopyridine as inhibitors of the JAK family of kinases - Google
Patents US10981911B2 - Imidazopyrrolopyridine as inhibitors of the JAK family of kinases …