Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Focal segmental glomerulosclerosis (FSGS) describes both a common lesion in progressive
kidney disease, and a disease characterized by marked proteinuria and podocyte injury …

Results We identified causing mutations in 34%(37/110) of SRNS patients, representing
67%(16/24) familial and 25%(21/86) sporadic cases. Mutations were detected in 100% of …

Idiopathic nephrotic syndrome resistant to standard treatments remains a therapeutic
dilemma in pediatric nephrology. To test whether the anti-CD20 monoclonal antibody …

SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of
protein complexes through physical interactions with a pool of proline-rich/noncanonical …

Several genes have been implicated in genetic forms of nephrotic syndrome occurring in
children. It is now known that the phenotypes associated with mutations in these genes …

Idiopathic nephrotic syndrome (INS) describes a group of pathologies of the renal
glomerulus that result in the classic triad of heavy proteinuria, oedema and …

Focal segmental glomerulosclerosis (FSGS) is a common cause of steroid-resistant
nephrotic syndrome in children and adults. Although FSGS is considered a podocyte …

Kidney podocytes are highly differentiated epithelial cells that form interdigitating foot
processes with bridging slit diaphragms (SDs) that regulate renal ultrafiltration. Podocyte …

Monogenic forms of Steroid-Resistant Nephrotic Syndrome (SRNS) have been widely
characterized, but genetic screening paradigms preferentially address congenital, infantile …