Recent advances in the synthesis of bioactive glycohybrids via click-chemistry
Carbohydrates, traditionally known for their energy-providing role, have gained significant
attention in drug discovery due to their diverse bioactivities and stereodiversity. However …
attention in drug discovery due to their diverse bioactivities and stereodiversity. However …
Copper-Catalyzed Cross-Dehydrogenative N2-Coupling of NH-1,2,3-Triazoles with N,N -Dialkylamides: N-Amidoalkylation of NH-1,2,3-Triazoles
X Deng, X Lei, G Nie, L Jia, Y Li… - The Journal of Organic …, 2017 - ACS Publications
An efficient copper-catalyzed C–N bond formation by N–H/C–H cross-dehydrogenative
coupling (CDC) between NH-1, 2, 3-triazoles and N, N-dialkylamides has been developed …
coupling (CDC) between NH-1, 2, 3-triazoles and N, N-dialkylamides has been developed …
Synthesis and characterization of a recyclable graphene oxide-surface-engineered copper (II) Schiff base complex: Catalytic application in synthesis of 1, 2, 3 …
A new graphene oxide (GO) supported Cu (II) Schiff base complex (GO-SB-Cu) has been
synthesized by utilizing Schiff base functionalized GO (GO-SB) and copper acetate in …
synthesized by utilizing Schiff base functionalized GO (GO-SB) and copper acetate in …
Recent Advances in the Synthesis of Bioactive Quinoline-Based 1, 2, 3-Triazoles via Cu-Catalyzed Huisgen 1, 3-Dipolar Cycloaddition (“Click Reaction”)
VV Kouznetsov, LY Vargas-Mendez… - Mini-Reviews in …, 2016 - ingentaconnect.com
Background: Quinoline and 1, 2, 3-triazoles have attracted increasing attention due to their
significant biological activities. Combination of these two scaffolds in one single molecule …
significant biological activities. Combination of these two scaffolds in one single molecule …
Synthesis of fully functionalized spirostanic 1, 2, 3-triazoles by the three component reaction of diosgenin azides with acetophenones and aryl aldehydes and their …
ME Mironov, TV Rybalova, MA Pokrovskii, F Emaminia… - Steroids, 2023 - Elsevier
Diosgenin is of significant interest due to its biological activity and synthetic application. In
this study, we report the synthesis of a series of spirostanic 1, 4, 5-trisubstituted 1, 2, 3 …
this study, we report the synthesis of a series of spirostanic 1, 4, 5-trisubstituted 1, 2, 3 …
[HTML][HTML] Synthesis, molecular docking studies and ADME prediction of some new triazoles as potential antimalarial agents
The challenges concerning the control of malaria remain due to the continuous emergence
of drug resistant strains. Over the years, the use, misuse, and abuse of antimalarials have …
of drug resistant strains. Over the years, the use, misuse, and abuse of antimalarials have …
Regioselective Synthesis of N2-Alkylated-1,2,3 Triazoles and N1-Alkylated Benzotriazoles: Cu2S as a Recyclable Nanocatalyst for Oxidative Amination of N,N …
S Gupta, N Chandna, AK Singh… - The Journal of Organic …, 2018 - ACS Publications
Copper chalcogenide nanoparticles (Cu2S) synthesized for the first time from a single-
source precursor, CuSPh, act as highly efficient and reusable heterogeneous catalyst for …
source precursor, CuSPh, act as highly efficient and reusable heterogeneous catalyst for …
Discovery of novel 2, 4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R
Y Wang, S Chen, G Hu, J Wang, W Gou, D Zuo… - European Journal of …, 2018 - Elsevier
Aiming to explore novel anaplastic lymphoma kinase (ALK) and proto-oncogene tyrosine-
protein kinase ROS (ROS1) dual inhibitors to overcome crizotinib-resistant mutants, two …
protein kinase ROS (ROS1) dual inhibitors to overcome crizotinib-resistant mutants, two …
Synthesis, biological evaluation and molecular docking studies of novel 1, 2, 3-triazole-quinazolines as antiproliferative agents displaying ERK inhibitory activity
PSG Nunes, G da Silva, S Nascimento, SP Mantoani… - Bioorganic …, 2021 - Elsevier
ERK1/2 inhibitors have attracted special attention concerning the ability of circumventing
cases of innate or log-term acquired resistance to RAF and MEK kinase inhibitors. Based on …
cases of innate or log-term acquired resistance to RAF and MEK kinase inhibitors. Based on …
Synthesis, antitumor activity evaluation and mechanistic study of novel hederacolchiside A1 derivatives bearing an aryl triazole moiety
H Li, H Wang, Z Wang, H Yan, M Zhang, Y Liu… - Bioorganic & Medicinal …, 2018 - Elsevier
In an attempt to arrive at a more potent antitumor agent than the parent natural saponin
hederacolchiside A 1, 23 hederacolchiside A 1 derivatives (4a-4w) were synthesized via Cu …
hederacolchiside A 1, 23 hederacolchiside A 1 derivatives (4a-4w) were synthesized via Cu …