Activin/Nodal growth factors control a broad range of biological processes, including early
cell fate decisions, organogenesis and adult tissue homeostasis. Here, we provide an …

A major challenge to our understanding of the molecular mechanisms of Alzheimer's
disease (AD) has been the lack of physiologically relevant in vitro models which capture the …

Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in
vitro research window to the development of the cerebral cortex. However, a key player in …

The first lineage specification of pluripotent mouse epiblast segregates neuroectoderm (NE)
from mesoderm and definitive endoderm (ME) by mechanisms that are not well understood …

A fundamental question in developmental biology is whether there are mechanisms to
detect stem cells with mutations that, although not adversely affecting viability, would …

The efficient generation of striatal neurons from human embryonic stem cells (hESCs) and
induced pluripotent stem cells (hiPSCs) is fundamental for realising their promise in disease …

Background Alterations in neural excitation and inhibition cause a number of neurologic and
psychiatric disorders. In the cerebral cortex, excitation and inhibition are mediated by two …

Highlights•Cortical interneurons originate in the embryonic subcortical
telencephalon.•Spatial and temporal control of progenitor differentiation generates …

GABAergic interneurons regulate cortical neural networks by providing inhibitory inputs, and
their malfunction, resulting in failure to intricately regulate neural circuit balance, is …

The development of the cerebral cortex requires the tightly coordinated generation of
dozens of neuronal subtypes that will populate specific layers and areas. Recent studies …