The pathway from gene activation in the nucleus to mRNA translation and decay at specific
locations in the cytoplasm is both streamlined and highly interconnected. This review …

Recent work indicates that the posttranscriptional control of eukaryotic gene expression is
much more elaborate and extensive than previously thought, with essentially every step of …

PGC-1α plays a central role in maintaining mitochondrial and energy metabolism
homeostasis, linking external stimuli to transcriptional co-activation of genes involved in …

Many chromatin-binding proteins and protein complexes that regulate transcription also bind
RNA. One of these, Polycomb repressive complex 2 (PRC2), deposits the H3K27me3 mark …

The transport of RNA molecules from the nucleus to the cytoplasm is fundamental for gene
expression. The different RNA species that are produced in the nucleus are exported …

RNA has been implicated in the recruitment of chromatin modifiers, and previous studies
have provided evidence in favor and against this idea. RNase treatment of chromatin is …

In yeast, the TREX complex contains the THO transcription elongation complex, which
functions in direct cotranscriptional recruitment of the mRNA export proteins Sub2 and Yra1 …

Messenger RNAs (mRNAs) are at the center of the central dogma of molecular biology. In
eukaryotic cells, these long ribonucleic acid polymers do not exist as naked transcripts; …

Pre-mRNAs undergo splicing to remove introns, and the spliced mRNA is exported to the
cytoplasm for translation. Here we investigated the mechanism for recruitment of the …

To determine the prevalence of cotranscriptional splicing in Drosophila, we sequenced
nascent RNA transcripts from Drosophila S2 cells as well as from Drosophila heads. Eighty …