Cells have evolved a complex network of biochemical pathways, collectively known as the
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …

Micronuclei are small membrane-bounded compartments with a DNA content encapsulated
by a nuclear envelope and spatially separated from the primary nucleus. Micronuclei have …

DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity.
To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries …

Nonhomologous end-joining (NHEJ) and homologous recombination (HR) are the primary
pathways for repairing DNA double-strand breaks (DSBs) during interphase, whereas …

Chromothripsis, the shattering and imperfect reassembly of one (or a few) chromosome (s),
is an ubiquitous mutational process generating localized and complex chromosomal …

Abstract BRCA1/2-mutated cancer cells adapt to the genome instability caused by their
deficiency in homologous recombination (HR). Identification of these adaptive mechanisms …

Sister chromatid exchanges (SCEs) are products of joint DNA molecule resolution, and are
considered to form through homologous recombination (HR). Indeed, SCE induction upon …

Complex genome rearrangements can be generated by the catastrophic pulverization of
missegregated chromosomes trapped within micronuclei through a process known as …

The DNA damage response (DDR) is critical for maintaining cellular homeostasis and
genome integrity. Mounting evidence has shown that posttranslational protein modifications …

ATR checkpoint signaling is crucial for cellular responses to DNA replication impediments.
Using an optogenetic platform, we show that TopBP1, the main activator of ATR, self …