Anxiety disorders, depression, and alcohol use disorder are common neuropsychiatric
diseases that often occur together. Oxidative stress has been suggested to contribute to their …

Accumulating data highlight the contribution of brain mitochondria and bioenergetics to
psychiatric disorders and stress-related pathologies. Although anxiety has not received …

The significant increase in worldwide morbidity and mortality from non-communicable
diseases (NCDs) indicates that the efficacy of existing strategies addressing this crisis may …

BACKGROUND: Although anxiety disorders are the most prevalent psychiatric disorders, no
molecular biomarkers exist for their premorbid diagnosis, accurate patient …

Bradykinin (BK), generated from high-molecular-weight kininogen (HK) is the major
mediator of swelling attacks in hereditary angioedema (HAE), a disease associated with C1 …

The mammalian brain has high energy demands, which may become higher in response to
environmental challenges such as psychogenic stress exposure. Therefore, efficient …

Mice are increasingly overtaking the rat model organism in important aspects of anxiety
research, including drug development. However, translating the results obtained in mouse …

Our analysis shows that there is a large interest in performing anxiety research innovatively.
However, efforts are highly divergent and result in large numbers of poorly validated and …

The synapse is a particularly important compartment of neurons. To reveal its molecular
characteristics we isolated whole brain synaptic (sMito) and non-synaptic mitochondria …

Tau protein in dendrites and synapses has been recently implicated in synaptic
degeneration and neuronal malfunction. Chronic stress, a well-known inducer of …