The genomes of virtually all organisms contain repetitive sequences that are generated by
the activity of transposable elements (transposons). Transposons are mobile genetic …

Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

Background: B-cell depletion with rituximab is commonly used for patients with systemic
lupus erythematosus (SLE) that is refractory to conventional therapy, but it yields variable …

Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

Following fifteen years of research, neutrophil extracellular traps (NETs) are widely reported
in a large range of inflammatory infectious and non-infectious diseases. Cumulating …

Objective The role of interferon‐α (IFNα) in the pathogenesis of systemic lupus
erythematosus (SLE) is strongly supported by gene expression studies. The aim of this study …

Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation
activates plasmacytoid dendritic cells and serves as a source of autoantigens in SLE. We …

Objectives Despite advances in systemic lupus erythematosus (SLE) treatment, many
patients suffer from the disease and side effects. Atacicept is a fusion protein that blocks B …

Recent genetic studies have revealed shared immunological mechanisms in several
immune-related disorders that further our understanding of the development and …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the
aberrant production of a broad and heterogenous group of autoantibodies. Even though the …