Non-alcoholic fatty liver disease (NAFLD) is one the fastest emerging manifestations of the
metabolic syndrome worldwide. Non-alcoholic steatohepatitis (NASH), the progressive form …

Background: Maternal obesity and maternal overnutrition, can lead to epigenetic alterations
during pregnancy and these alterations can influence fetal and neonatal phenotype which …

With the increasing prevalence of obesity in women of reproductive age there is a need to
understand the ramifications of this on offspring. The purpose of this study is to investigate …

Biological sex is a fundamental source of phenotypic variability across species. Males and
females have different nutritional needs and exhibit differences in nutrient digestion and …

The prevalence of maternal obesity is increasing at an alarming rate, and is providing a
major challenge for obstetric practice. Adverse effects on maternal and fetal health are …

Circadian clocks confer 24-h periodicity to biological systems, to ultimately maximize energy
efficiency and promote survival in a world with regular environmental light cycles. In …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors which belong to the nuclear hormone receptor superfamily. They regulate key …

Lipotoxicity is a phenomenon of lipid-induced cellular injury in nonadipose tissue. Excess of
free saturated fatty acids (SFAs) contributes to hepatic injury in nonalcoholic fatty liver …

The incidence of obesity is rising rapidly worldwide with the consequence that more women
are entering pregnancy overweight or obese. This leads to an increased incidence of clinical …

Oxidative stress is a major cellular event that occurs in the placenta, fulfilling critical
physiological roles in non-pathological pregnancies. However, exacerbated oxidative stress …