[HTML][HTML] Multimodal general anesthesia: theory and practice
EN Brown, KJ Pavone, M Naranjo - Anesthesia & analgesia, 2018 - journals.lww.com
Balanced general anesthesia, the most common management strategy used in anesthesia
care, entails the administration of different drugs together to create the anesthetic state …
care, entails the administration of different drugs together to create the anesthetic state …
Clinical electroencephalography for anesthesiologists: part I: background and basic signatures
PL Purdon, A Sampson, KJ Pavone, EN Brown - Anesthesiology, 2015 - pubs.asahq.org
The widely used electroencephalogram-based indices for depth-of-anesthesia monitoring
assume that the same index value defines the same level of unconsciousness for all …
assume that the same index value defines the same level of unconsciousness for all …
[HTML][HTML] Comfort and patient-centred care without excessive sedation: the eCASH concept
JL Vincent, Y Shehabi, TS Walsh… - Intensive care …, 2016 - Springer
We propose an integrated and adaptable approach to improve patient care and clinical
outcomes through analgesia and light sedation, initiated early during an episode of critical …
outcomes through analgesia and light sedation, initiated early during an episode of critical …
The neural circuits underlying general anesthesia and sleep
OA Moody, ER Zhang, KF Vincent, R Kato… - Anesthesia & …, 2021 - journals.lww.com
General anesthesia is characterized by loss of consciousness, amnesia, analgesia, and
immobility. Important molecular targets of general anesthetics have been identified, but the …
immobility. Important molecular targets of general anesthetics have been identified, but the …
The ageing brain: age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia
PL Purdon, KJ Pavone, O Akeju… - British journal of …, 2015 - academic.oup.com
Background Anaesthetic drugs act at sites within the brain that undergo profound changes
during typical ageing. We postulated that anaesthesia-induced brain dynamics observed in …
during typical ageing. We postulated that anaesthesia-induced brain dynamics observed in …
Dexmedetomidine: review, update, and future considerations of paediatric perioperative and periprocedural applications and limitations
M Mahmoud, KP Mason - British journal of anaesthesia, 2015 - academic.oup.com
Despite lack of paediatric labelling, contributions to the literature on paediatric applications
of dexmedetomidine have increased over recent years. Dexmedetomidine possesses many …
of dexmedetomidine have increased over recent years. Dexmedetomidine possesses many …
[HTML][HTML] Network properties in transitions of consciousness during propofol-induced sedation
M Lee, RD Sanders, SK Yeom, DO Won, KS Seo… - Scientific reports, 2017 - nature.com
Reliable electroencephalography (EEG) signatures of transitions between consciousness
and unconsciousness under anaesthesia have not yet been identified. Herein we examined …
and unconsciousness under anaesthesia have not yet been identified. Herein we examined …
[HTML][HTML] Association of electroencephalogram trajectories during emergence from anaesthesia with delirium in the postanaesthesia care unit: an early sign of …
S Hesse, M Kreuzer, D Hight, A Gaskell… - British journal of …, 2019 - Elsevier
Background Postoperative delirium is associated with an increased risk of morbidity and
mortality, especially in the elderly. Delirium in the postanaesthesia care unit (PACU) could …
mortality, especially in the elderly. Delirium in the postanaesthesia care unit (PACU) could …
[HTML][HTML] Nighttime dexmedetomidine for delirium prevention in non-mechanically ventilated patients after cardiac surgery (MINDDS): a single-centre, parallel-arm …
JZ Qu, A Mueller, TB McKay, MB Westover… - …, 2023 - thelancet.com
Background The delirium-sparing effect of nighttime dexmedetomidine has not been studied
after surgery. We hypothesised that a nighttime dose of dexmedetomidine would reduce the …
after surgery. We hypothesised that a nighttime dose of dexmedetomidine would reduce the …
Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep
O Akeju, EN Brown - Current opinion in neurobiology, 2017 - Elsevier
Highlights•Neural oscillations provide a framework for comparing general anesthesia and
sleep.•Anesthetic drugs do not induce the physiological neural oscillations of sleep.•Non …
sleep.•Anesthetic drugs do not induce the physiological neural oscillations of sleep.•Non …