Cu-catalyzed azide− alkyne cycloaddition
The Huisgen 1, 3-dipolar cycloaddition reaction of organic azides and alkynes1, 2 has
gained considerable attention in recent years due to the introduction in 2001 of Cu (1) …
gained considerable attention in recent years due to the introduction in 2001 of Cu (1) …
Historic perspectives on Annonaceous acetogenins from the chemical bench to preclinical trials
Studies on the Annonaceous acetogenins began after the first cytotoxic acetogenin, uvaricin,
was isolated in 1982. This attractive finding made many medicinal and natural product …
was isolated in 1982. This attractive finding made many medicinal and natural product …
Acetogenins from annonaceae
In recent decades, annonaceous acetogenins have become highly studied plant secondary
metabolites in terms of their isolation, structure elucidation, synthesis, biological evaluation …
metabolites in terms of their isolation, structure elucidation, synthesis, biological evaluation …
[图书][B] Progress in the chemistry of organic natural products
Termites (Isoptera), which are a suborder of the cockroaches, are the oldest eusocial insects
[1–3]. It is assumed that they diverged from the Cryptocercoidae, woodfeeding cockroaches …
[1–3]. It is assumed that they diverged from the Cryptocercoidae, woodfeeding cockroaches …
Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues
N Kojima, T Tanaka - Molecules, 2009 - mdpi.com
Most Annonaceous acetogenins are characterized by between one and three THF ring (s)
with one or two flanking hydroxyl group (s) in the center of a C32/34 fatty acid, and the …
with one or two flanking hydroxyl group (s) in the center of a C32/34 fatty acid, and the …
Structure–antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety
K Ohta, T Fushimi, M Okamura, A Akatsuka, S Dan… - RSC …, 2022 - pubs.rsc.org
We studied hybrid molecules of annonaceous acetogenins and mitochondrial complex I-
inhibiting insecticides to develop a novel anticancer agent. A structure–antitumor activity …
inhibiting insecticides to develop a novel anticancer agent. A structure–antitumor activity …
Nuevos fármacos inspirados en Annonáceas
D Cortes, L Moreno, J Párraga, A Galán… - Revista Brasileira de …, 2014 - SciELO Brasil
Los metabolitos secundarios activos (MSA) juegan un papel importante en el
descubrimiento de nuevos medicamentos. Moléculas naturales con esqueletos complejos …
descubrimiento de nuevos medicamentos. Moléculas naturales con esqueletos complejos …
Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells
Background Histone modifications in tumorigenesis are increasingly recognized as
important epigenetic factors leading to cancer. Increased phosphorylation levels of histone …
important epigenetic factors leading to cancer. Increased phosphorylation levels of histone …
Highly cytotoxic and neurotoxic acetogenins of the Annonaceae: new putative biological targets of squamocin detected by activity-based protein profiling
S Derbré, S Gil, M Taverna, C Boursier… - Bioorganic & medicinal …, 2008 - Elsevier
Acetogenins of the Annonaceae are strong inhibitors of mitochondrial complex I but
discrepancies in the structure/activity relationships pled the search for other targets within …
discrepancies in the structure/activity relationships pled the search for other targets within …
Synthesis of Acetogenin Analogs Comprising Pyrimidine Moieties Linked by Amine Bonds and Their Inhibitory Activity against Human Cancer Cell Lines
H Hosomi, A Akatsuka, S Dan, H Iwasaki… - Chemical and …, 2022 - jstage.jst.go.jp
Here, we synthesized three acetogenin analogs containing pyrimidine moieties linked by
amine bonds, which represent the skeleton structure of pyrimidifen, a mitochondrial complex …
amine bonds, which represent the skeleton structure of pyrimidifen, a mitochondrial complex …