Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and
aging increases the burden of CS in all major metabolic tissues. However, CS is also …

Aging is a gradual, continuous series of natural changes in biological, physiological,
immunological, environmental, psychological, behavioral, and social processes. Aging …

Fisetin has been shown to be beneficial for brain injury and age-related brain disease via
different mechanisms. The purpose of this study was to determine the presence of senescent …

Sarcopenia is a disease characterized by the progressive loss of skeletal muscle mass and
function that occurs with aging. The progression of sarcopenia is correlated with the onset of …

Dementia is a growing problem around the globe as the world's population continues to age.
Multiple studies have identified potentially modifiable risk factors for the development of …

Musculoskeletal research should synergistically investigate bone and muscle to inform
approaches for maintaining mobility and to avoid bone fractures. The relationship between …

Fisetin, a flavonoid naturally occurring in plants, fruits, and vegetables, has recently gained
attention for its potential role as a senotherapeutic agent for the treatment of age-related …

In a recent study published in Nature, Moiseeva and colleagues examined senescent cells,
including fibro/adipogenic progenitors (FAPs), muscle stem cells (MuSCs) and …

Background: Massive irreparable rotator cuff tears (MIRCTs) are among the most
challenging shoulder conditions to treat surgically. Supraspinatus tendon reconstruction …

Pdgfrα+ stromal cells are a group of cells specifically expressing Pdgfrα, which may be
mentioned with distinct names in different tissues. Importantly, the findings from numerous …