Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

Thiazole is one of the most important scaffolds in heterocyclic chemistry and drug design
and discovery. It is widely found in diverse pharmacologically active substances and in …

Three different series of ethylidenehydrazonothiazoles 5a-c, 6a-c, ethylidenehydrazono-1, 3-
thiazines 9a-i and ethylidenehydrazonothiazolidine 12 have been prepared via reactions of …

Thiazole derivatives are recognized to possess various biological activities as antiparasitic,
antifungal, antimicrobial and antiproliferative. The present work reports the synthesis of 22 …

Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are …

Neglected tropical diseases (NTDs) encompass a group of infectious diseases with a
protozoan etiology, high incidence, and prevalence in developing countries. As a result …

Leishmaniasis is a parasitic neglected tropical disease caused by various species of
Leishmania parasite. Despite tremendous advancements in the therapeutic sector and drug …

Abstract Twelve 2-(quinolin-4-ylmethylene) hydrazinecarbothioamide derivatives were
synthetized and their biological properties were investigated, among which, the ability to …

A novel series of 4-substituted 5-arylazo-2-[1-(pyrrol-3-yl) ethylidenehydrazinyl] thiazoles
and 5-arylazo-2-[1-(pyrrol-3-yl) ethylidenehydrazinyl]-2, 3-dihydrothiazol-3-amines was …

Thiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting
as primary pharmacophores) in many compounds that are useful to treat several diseases …