[HTML][HTML] Integration of Omics Data and Network Models to Unveil Negative Aspects of SARS-CoV-2, from Pathogenic Mechanisms to Drug Repurposing
L Bernardo, A Lomagno, PL Mauri, D Di Silvestre - Biology, 2023 - mdpi.com
Simple Summary SARS-CoV-2 caused the COVID-19 health emergency, affecting millions
of people worldwide. Samples collected from hospitalized or dead patients from the early …
of people worldwide. Samples collected from hospitalized or dead patients from the early …
Using machine‐learning‐driven approaches to boost hot‐spot's knowledge
N Rosário‐Ferreira, AMJJ Bonvin… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Understanding protein–protein interactions (PPIs) is fundamental to describe and to
characterize the formation of biomolecular assemblies, and to establish the energetic …
characterize the formation of biomolecular assemblies, and to establish the energetic …
Integrated bioinformatics analysis to identify alternative therapeutic targets for Alzheimer's disease: insights from a synaptic machinery perspective
H Ceylan - Journal of Molecular Neuroscience, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common type of dementia, is a serious
neurodegenerative disease that has no cure yet, but whose symptoms can be alleviated with …
neurodegenerative disease that has no cure yet, but whose symptoms can be alleviated with …
Bioinformatics‐based identification of hepatocellular carcinoma‐associated hub genes and assessment of the restorative effect of tannic acid in rat liver exposed to …
H Tosun, H Karadas, H Ceylan - Cancer Medicine, 2024 - Wiley Online Library
Background Hepatocellular carcinoma (HCC) is the most common type of primary liver
cancer, occurring mostly in individuals with chronic liver disease, but biomarkers for …
cancer, occurring mostly in individuals with chronic liver disease, but biomarkers for …
[HTML][HTML] Identification of critical genes and molecular pathways in COVID-19 myocarditis and constructing gene regulatory networks by bioinformatic analysis
F Zhang, C Yu, W Xu, X Li, J Feng, H Shi, J Yang… - Plos one, 2022 - journals.plos.org
Background There is growing evidence of a strong relationship between COVID-19 and
myocarditis. However, there are few bioinformatics-based analyses of critical genes and the …
myocarditis. However, there are few bioinformatics-based analyses of critical genes and the …
[HTML][HTML] Drug genetic associations with COVID-19 manifestations: a data mining and network biology approach
T Charitou, PI Kontou, IA Tamposis… - The …, 2022 - nature.com
Available drugs have been used as an urgent attempt through clinical trials to minimize
severe cases of hospitalizations with Coronavirus disease (COVID-19), however, there are …
severe cases of hospitalizations with Coronavirus disease (COVID-19), however, there are …
[HTML][HTML] In-silico discovery of common molecular signatures for which SARS-CoV-2 infections and lung diseases stimulate each other, and drug repurposing
COVID-19 caused by SARS-CoV-2 is a global health issue. It is yet a severe risk factor to the
patients, who are also suffering from one or more chronic diseases including different lung …
patients, who are also suffering from one or more chronic diseases including different lung …
The hepatoprotective potential of tannic acid against doxorubicin‐induced hepatotoxicity: Insights into its antioxidative, anti‐inflammatory, and antiapoptotic …
Doxorubicin (DOX), which is frequently used in cancer treatment, has limited clinical use due
to adverse effects on healthy tissues, especially the liver. Therefore, it is necessary to …
to adverse effects on healthy tissues, especially the liver. Therefore, it is necessary to …
[HTML][HTML] A systems biology approach for investigating significantly expressed genes among COVID-19, hepatocellular carcinoma, and chronic hepatitis B
B Sokouti - Egyptian Journal of Medical Human Genetics, 2022 - Springer
Abstract Background Worldwide, COVID-19's death rate is about 2%, considering the
incidence and mortality. However, the information on its complications in other organs …
incidence and mortality. However, the information on its complications in other organs …
A nine-hub-gene signature of metabolic syndrome identified using machine learning algorithms and integrated bioinformatics
G Liu, S Luo, Y Lei, J Wu, Z Huang, K Wang… - …, 2021 - Taylor & Francis
Early risk assessments and interventions for metabolic syndrome (MetS) are limited because
of a lack of effective biomarkers. In the present study, several candidate genes were …
of a lack of effective biomarkers. In the present study, several candidate genes were …