Soon after they were first described in 1990, aptamers were largely recognized as a new
class of biological ligands that can rival antibodies in various analytical, diagnostic, and …

Aptamers are short single-stranded DNA or RNA oligonucleotides that can selectively bind
to small molecular ligands or protein targets with high affinity and specificity, by acquiring …

With the growing number of genetic association studies, the genotype-phenotype atlas has
become increasingly more complex, yet the functional consequences of most disease …

Proteins circulating in the blood are critical for age-related disease processes; however, the
serum proteome has remained largely unexplored. To this end, 4137 proteins covering most …

Genome-wide association studies (GWAS) with intermediate phenotypes, like changes in
metabolite and protein levels, provide functional evidence to map disease associations and …

Background Human skeletal muscle is composed of three major fiber types, referred to as
type 1, 2A, and 2X fibers. This heterogeneous cellular composition complicates the …

Aptamers are single-stranded DNA or RNA molecules capable of tightly binding to specific
targets. These functional nucleic acids are obtained by an in vitro Darwinian evolution …

Asthma is characterised by heterogeneous clinical phenotypes. Our objective was to
determine molecular phenotypes of asthma by analysing sputum cell transcriptomics from …

Aptamers and SELEX (systematic evolution of ligands by exponential enrichment)
technology have gained increasing attention over the past 25 years. Despite their functional …

Satellite cells are adult myogenic stem cells that repair damaged muscle. The enduring
capacity for muscle regeneration requires efficient satellite cell expansion after injury, their …