For those using drugs to treat infants and children, the integration of developmental
pharmacology is crucial to appropriate clinical practice. Changes in metabolic capacity …

Fetal exposure to xenobiotics is modulated to a considerable degree by the metabolic
capabilities of the mother and the placenta. However, once liberated from the uterine …

LOCATE FREQUENTLY USED INFORMATION EASILY AND QUICKLYWorking in the
laboratory or office, you use a diverse assortment of basic information to design, conduct …

In children, the therapeutic benefits and potential risks associated with drug treatment may
be different from those in adults and will depend on the exposure, receptor sensitivity and …

Importance Federal legislation has led to a notable increase in pediatric studies submitted to
the Food and Drug Administration (FDA), resulting in new pediatric information in product …

The need to establish drug-dosing guidelines in children highlights the challenges
associated with the development of phases I and II pediatric clinical trials. These challenges …

The advances in developmental pharmacokinetics during the past decade reside with an
enhanced understanding of the influence of growth and development on drug absorption …

Purpose Compound solubility serves as a surrogate indicator of oral biopharmaceutical
performance. Between infancy and adulthood, marked compositional changes in …

Nanotechnology has become a key tool to overcome the main (bio) pharmaceutical
drawbacks of drugs and to enable their passive or active targeting to specific cells and …

Background: Gastrooesophageal reflux afflicts up to 7% of all infants. Histamine2 receptor
antagonists are the most commonly prescribed medications for this disorder, but few …