New local treatments based on electromagnetic fields have been developed as non‐
surgical and minimally invasive treatments of tumors. In particular, short electric pulses can …

Nanosecond Pulsed Electric Field (nsPEF) is an electrostimulation technique first developed
in 1995; nsPEF requires the delivery of a series of pulses of high electric fields in the order of …

Background Nanosecond, megavolt-per-meter pulsed electric fields scramble membrane
phospholipids, release intracellular calcium, and induce apoptosis. Flow cytometric and …

The change in the membrane potential of Jurkat cells in response to nanosecond pulsed
electric fields was studied for pulses with a duration of 60ns and maximum field strengths …

All living cells are surrounded by plasma membranes that separate the cell interior from the
extracellular environment and are responsible for the selective permeability of cells. 1 The …

Biological and Medical Aspects of Electromagnetic Fields examines potential health
hazards, exposure standards, and medical applications of electromagnetic (EM) fields. The …

Models for electric field interactions with biological cells predict that pulses with durations
shorter than the charging time of the outer membrane can affect intracellular structures …

Nanosecond electrical pulses have been successfully used to treat melanoma tumors by
using needle arrays as pulse delivery systems. Reducing the pulse duration of intense …

When delivered to cells, very short duration, high electric field pulses (nanoelectropulses)
induce primarily intracellular events. We present evidence that this emerging modality may …

We have identified a new, nanosecond pulsed electric field (nsPEF) therapy capable of
eliminating murine melanomas located in the skin with a single treatment. When these …