SUMMARY 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are best
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …

Parkinson's disease is a debilitating, age-associated movement disorder. A central aspect of
the pathophysiology of Parkinson's disease is the progressive demise of midbrain dopamine …

Evolving concepts on Parkinson's disease (PD) pathology suggest that α-synuclein (aSYN)
promote dopaminergic neuron dysfunction and death through accumulating in the …

α-Synuclein (αSyn) aggregation and mitochondrial dysfunction both contribute to the
pathogenesis of Parkinson disease (PD). Although recent studies have suggested that …

The protein aggregation that occurs in neurodegenerative diseases is classically thought to
occur as an undesirable, nonfunctional byproduct of protein misfolding. This model contrasts …

In a research environment dominated by reductionist approaches to brain disease
mechanisms, gene network analysis provides a complementary framework in which to tackle …

Alternative polyadenylation (APA) plays an essential role in brain development; however,
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …

Genome Wide Association Studies (GWAS) have mapped thousands of genetic variants
associated with complex disease risk and regulating quantitative traits, thus exploiting an …

Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …

The continuously prolonged human lifespan is accompanied by increase in
neurodegenerative diseases incidence, calling for the development of inexpensive blood …