Abstract Information storage and retrieval is essential for all life. In biology, information is
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …

Glaucoma is the world's leading irreversible blinding eye disease. Lowering intraocular
pressure is currently the only effective clinical treatment. However, there is a lack of long …

The optic nerve head is thought to be the site of initial injury to retinal ganglion cell injury in
glaucoma. In the initial segment of the optic nerve directly behind the globe, the ganglion …

Introduction Age-related diseases such as glaucoma, a leading cause of blindness, are
having an upward trend due to an aging society. In glaucoma, some patients display altered …

Introduction Animal models are widely used in glaucoma-related research. Since the
elevated intraocular pressure (IOP) is a major risk factor underlying the disease …

Glaucoma, a chronic neurodegenerative disease, is a leading cause of age-related
blindness worldwide and characterized by the progressive loss of retinal ganglion cells …

Aging is one of the most serious risk factors for glaucoma, and according to age-
standardized prevalence, glaucoma is the second leading cause of legal blindness …

Background Age-related eye diseases (AREDs) have become increasingly prevalent with
the aging population, serving as the leading causes of visual impairment worldwide …

Increased cellular senescence burden contributes in part to age-related organ dysfunction
and pathologies. In our study, using mouse models of natural aging, we observed structural …

Glaucoma is a common neurodegenerative disorder characterized by retinal ganglion cell
death, astrocyte reactivity in the optic nerve, and vision loss. Currently, lowering the …