[HTML][HTML] The taste of heavy metals: gene regulation by MTF-1

V Günther, U Lindert, W Schaffner - Biochimica et Biophysica Acta (BBA) …, 2012 - Elsevier
The metal-responsive transcription factor-1 (MTF-1, also termed MRE-binding transcription
factor-1 or metal regulatory transcription factor-1) is a pluripotent transcriptional regulator …

Aberrant expression of microRNAs in bladder cancer

H Yoshino, N Seki, T Itesako, T Chiyomaru… - Nature Reviews …, 2013 - nature.com
MicroRNAs (miRNAs), a class of small noncoding RNAs, regulate protein-coding gene
expression by repressing translation or cleaving RNA transcripts in a sequence-specific …

miR-200b and miR-200c as prognostic factors and mediators of gastric cancer cell progression

H Tang, M Deng, Y Tang, X Xie, J Guo, Y Kong… - Clinical Cancer …, 2013 - AACR
Purpose: The purpose of this study was to investigate the clinicopathologic significance and
potential role of miR-200b and miR-200c in the development and progression of gastric …

The microRNA-183 cluster: the family that plays together stays together

S Dambal, M Shah, B Mihelich, L Nonn - Nucleic acids research, 2015 - academic.oup.com
Abstract The microRNA (miR) 183 cluster, which is comprised of miRs-183,-96 and-182, is
also a miR family with sequence homology. Despite the strong similarity in the sequences of …

Zinc and zinc transporters in prostate carcinogenesis

V Kolenko, E Teper, A Kutikov, R Uzzo - Nature Reviews Urology, 2013 - nature.com
The healthy human prostate accumulates the highest level of zinc of any soft tissue in the
body. This unique property is retained in BPH, but is lost in prostatic malignancy, which …

A review of currently identified small molecule modulators of microRNA function

EN Van Meter, JA Onyango, KA Teske - European journal of medicinal …, 2020 - Elsevier
Abstract microRNAs are small, noncoding RNA that negatively regulate gene expression.
Since their discovery in 1993, approximately 2500 human mature microRNAs have been …

Organ-specific cancer metabolism and its potential for therapy

I Elia, R Schmieder, S Christen, SM Fendt - Metabolic control, 2016 - Springer
Targeting cancer metabolism has the potential to lead to major advances in tumor therapy.
Numerous promising metabolic drug targets have been identified. Yet, it has emerged that …

MicroRNA-182-5p Promotes Cell Invasion and Proliferation by Down Regulating FOXF2, RECK and MTSS1 Genes in Human Prostate Cancer

H Hirata, K Ueno, V Shahryari, G Deng, Y Tanaka… - PloS one, 2013 - journals.plos.org
Recently miR-182 has been reported to be over-expressed in prostate cancer (PC) tissues,
however detailed functional analysis of miR-182-5p has not been carried out. The purpose …

Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAs

HC Martin, S Wani, AL Steptoe, K Krishnan, K Nones… - Genome biology, 2014 - Springer
Background MicroRNAs (miRNAs) bind to mRNAs and target them for translational inhibition
or transcriptional degradation. It is thought that most miRNA-mRNA interactions involve the …

Advances of zinc signaling studies in prostate cancer

D Li, DB Stovall, W Wang, G Sui - International Journal of Molecular …, 2020 - mdpi.com
Prostate cancer (PCa) is one of the most common cancers and the second leading cause of
cancer-related death among men worldwide. Despite progresses in early diagnosis and …