Cardiovascular diseases (CVD) are complex entities with heterogenous pathophysiologic
mechanisms and increased oxidative stress has been viewed as one of the potential …

Vitamin D is known to elicit a vasoprotective effect, while vitamin D deficiency is a risk factor
for endothelial dysfunction (ED). ED is characterized by reduced bioavailability of a potent …

Background: Chronic activation of the innate immune system drives inflammation and
contributes directly to atherosclerosis. We previously showed that macrophages in the …

Medical diagnosis and therapy are essential for providing patients with proper care,
although inefficient diagnosis and therapy are usually associated with either improper …

Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently,
compelling evidence has arisen for the role of monocytes and neutrophils and a particular …

1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …

Evidence has demonstrated that a new class of anti-diabetic drugs, sodium-glucose co-
transporter 2 (SGLT2) inhibitors, could exert beneficial effects on atherosclerotic …

Despite improvements in interventional and pharmacological therapy of atherosclerotic
disease, it is still the leading cause of death in the developed world. Hence, there is a need …

Background and aims Proprotein convertase subtilisin/kexin 9 (PCSK9) has emerged as a
popular target in the development of new cholesterol-lowering drugs and therapeutic …