Excessive exposure to polycyclic aromatic hydrocarbons (PAHs) often results in lung cancer,
a disease with the highest cancer mortality in the United States. After entry into the lung …

Significance: Particulate matter (PM) air pollution is a leading cause of global cardiovascular
morbidity and mortality. Understanding the biological action of PM is of particular importance …

Polycyclic aromatic hydrocarbons (PAHs) are often detected in the environment and are
regarded as endocrine disruptors. We here designated mixtures of PAHs in the environment …

Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that
occur in complex mixtures. Several PAHs are known or suspected mutagens and/or …

Tobacco smoking is an extremely addictive and harmful form of nicotine (NIC) consumption,
but unfortunately also the most prevalent. Although disproportionately high frequencies of …

Objective—Exposure to dioxins has been shown to contribute to the development of
inflammatory diseases, such as atherosclerosis. Macrophage-mediated inflammation is a …

Tobacco smoke contains a variety of genotoxic carcinogens that form adducts with DNA and
protein in the tissues of smokers. Not only are these biochemical events relevant to the …

The term polycyclic organic matter (POM) defines a broad class of compounds that generally
includes all organic structures containing three or more fused aromatic rings. These …

DNA polymerase (pol) κ is one of the so-called translesion polymerases involved in
replication past DNA lesions. Bypass events have been studied with a number of chemical …

Previous studies have shown that replicative bacterial and viral DNA polymerases are able
to bypass the mutagenic lesions O 6-methyl and-benzyl (Bz) G. Recombinant human …