Regulatory T cells in the treatment of disease
Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …
patients with systemic or organ-specific autoimmune diseases or those receiving …
A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity
The immune system ensures optimum T-effector (Teff) immune responses against invading
microbes and tumor antigens while preventing inappropriate autoimmune responses …
microbes and tumor antigens while preventing inappropriate autoimmune responses …
Phenotypical characterization of regulatory T cells in humans and rodents
AL Rodríguez-Perea, ED Arcia… - Clinical & …, 2016 - academic.oup.com
Regulatory T cells (Tregs) constitute a fascinating subpopulation of CD4+ T cells due to their
ability to limit the immune response against self and non-self antigens. Murine models and …
ability to limit the immune response against self and non-self antigens. Murine models and …
PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 …
Regulatory T (T reg) cells act as terminators of T cell immuniy during acute phase of viral
infection; however, their role and suppressive mechanism in chronic viral infection are not …
infection; however, their role and suppressive mechanism in chronic viral infection are not …
Recruitment and expansion of tregs cells in the tumor environment—how to target them?
J Cinier, M Hubert, L Besson, A Di Roio, C Rodriguez… - Cancers, 2021 - mdpi.com
Simple Summary The immune response against cancer is generated by effector T cells,
among them cytotoxic CD8+ T cells that destroy cancer cells and helper CD4+ T cells that …
among them cytotoxic CD8+ T cells that destroy cancer cells and helper CD4+ T cells that …
Glucocorticoid‐induced tumour necrosis factor receptor‐related protein: a key marker of functional regulatory T cells
Glucocorticoid‐induced tumour necrosis factor receptor‐related protein (GITR, TNFRSF18,
and CD357) is expressed at high levels in activated T cells and regulatory T cells (Tregs). In …
and CD357) is expressed at high levels in activated T cells and regulatory T cells (Tregs). In …
Low dose cyclophosphamide: mechanisms of T cell modulation
MT Madondo, M Quinn, M Plebanski - Cancer treatment reviews, 2016 - Elsevier
Cyclophosphamide is considered one of the most successful chemotherapy drugs and is
listed on the World Health Organisations List of Essential Medicines. Since its initial …
listed on the World Health Organisations List of Essential Medicines. Since its initial …
Alemtuzumab-induced immune phenotype and repertoire changes: implications for secondary autoimmunity
Alemtuzumab is a monoclonal antibody that causes rapid depletion of CD52-expressing
immune cells. It has proven to be highly efficacious in active relapsing–remitting multiple …
immune cells. It has proven to be highly efficacious in active relapsing–remitting multiple …
[HTML][HTML] Immunotherapy for Parkinson's disease
AD Schwab, MJ Thurston, J Machhi, KE Olson… - Neurobiology of …, 2020 - Elsevier
With the increasing prevalence of Parkinson's disease (PD), there is an immediate need to
interdict disease signs and symptoms. In recent years this need was met through therapeutic …
interdict disease signs and symptoms. In recent years this need was met through therapeutic …
Immune response mechanisms against AAV vectors in animal models
AT Martino, DM Markusic - Molecular Therapy-Methods & Clinical …, 2020 - cell.com
Early preclinical studies in rodents and other species did not reveal that vector or transgene
immunity would present a significant hurdle for sustained gene expression. While there was …
immunity would present a significant hurdle for sustained gene expression. While there was …