Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

Exosomes are small extracellular vesicles of∼ 30 to 150 nm that are secreted by all cells,
abundant in all biofluids, and play important roles in health and disease. However, details …

Amino acid (AA) is a potent mitogen that controls growth and metabolism. Here we describe
the identification of Rab1 as a conserved regulator of AA signaling to mTORC1. AA …

A wide variety of signaling proteins are modified by covalently linked fatty acids and/or
prenyl groups. These hydrophobic moieties, which include myristate, palmitate, farnesyl and …

Integrin trafficking plays an important role in cellular motility and cytokinesis. Integrins
undergo constant endo/exocytic shuttling to facilitate the dynamic regulation of cell …

Cytotoxic T lymphocytes (CTLs) play a critical role in the immune system; they are able to
recognize and destroy virally infected and tumorigenic cells. Specific recognition of MHC …

Dynamic turnover of integrin cell adhesion molecules to and from the cell surface is central
to cell migration. We report for the first time an association between integrins and Rab …

Covering: up to July 2008 Ribosomally synthesized bacterial natural products rival the
nonribosomal peptides in their structural and functional diversity. The last decade has seen …

CRISPR-based gene-drive systems, which copy themselves via gene conversion mediated
by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector …