Peptides have many advantages over traditional therapeutics, including small molecules
and other biologics, because of their low toxicity and immunogenicity, while still exhibiting …

High-density lipoproteins (HDL) are complex endogenous nanoparticles involved in
important functions such as reverse cholesterol transport and immunomodulatory activities …

Therapeutic nucleic acids represent a powerful class of drug molecules to control gene
expression and protein synthesis. A major challenge in this field is that soluble …

Abstract Ethnopharmacological relevance Tiaogan Daozhuo Formula (TGDZF) is a common
formulation against atherosclerosis, however, there is limited understanding of its …

Nowadays, there has been an increasing utilization of nanomedicines for disease treatment.
Nanodiscs (NDs) have emerged as a novel platform technology that garners significant …

Preclinical, clinical and epidemiologic studies have established the potent anticancer and
radiosensitisation effects of HMG-CoA reductase inhibitors (statins). However, the low …

Nanodisc (ND)-forming membrane scaffold proteins or peptides developed from
apolipoprotein AI (apoA-I) have led to considerable promise in structural biology and …

Aim: The impacts of synthetic high-density lipoprotein (sHDL) phospholipid components on
anti-sepsis effects were investigated. Methods: sHDL composed with ApoA-I mimetic peptide …

Nanodiscs are discoidal particles in which a lipid bilayer is encircled by amphipathic
molecules such as proteins, peptides, or synthetic polymers. The apolipoprotein-AI-derived …

The majority of clinically approved nanoparticle-mediated therapeutics are lipid
nanoparticles (LNPs), and most of these LNPs are liposomes containing cholesterol. LNP …