Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates
almost all immune regulatory processes, including those that are involved in tumor cell …

Metastatic disease is the leading cause of death among cancer patients and involves a
complex and inefficient process. Every step of the metastatic process can be rate limiting …

Natural killer T (NKT) cells are a subset of CD1d-restricted T cells at the interface between
the innate and adaptive immune system. NKT cells can be subdivided into functional …

Breast cancer (BC) is the main cause of cancer-related mortality among women globally.
Despite substantial advances in the identification and management of primary tumors …

Breast cancer is characterized by cellular and molecular heterogeneity. Several molecular
events are involved in controlling malignant cell processes. In this sense, there is an …

Hepatocellular carcinoma (HCC) is currently the third leading cause of cancer mortality and
a common poor-prognosis malignancy due to postoperative recurrence and metastasis …

The activating/co-stimulatory receptor NKG2D (natural-killer group 2, member D) is
expressed on the surface of all human NK, NKT, CD8+ T, and subsets of γδ+ T cells. The …

Background Diffuse gliomas are poorly immunogenic, fatal brain tumors. The basis for
insufficient antitumor immunity in diffuse gliomas is unknown. Gain-of-function mutations in …

Abstract Triple-Negative Breast Cancer (TNBC) is one of the most aggressive and hot BC
subtypes. Our research group has recently shed the light on the utility of natural compounds …

Human and mouse NKG 2D ligands (NKG 2 DL s) are absent or only poorly expressed by
most normal cells but are upregulated by cell stress, hence, alerting the immune system in …