A review of MMP-2 structures and binding mode analysis of its inhibitors to strategize structure-based drug design

S Sanyal, SA Amin, P Banerjee, S Gayen… - Bioorganic & Medicinal …, 2022 - Elsevier
The protease enzyme, matrix metalloproteinase-2 (MMP-2) has been a target of choice for
the drug development due to its multi-façade involvement in numerous diseased conditions …

Macrocycles and macrocyclization in anticancer drug discovery: Important pieces of the puzzle

C Zhang, F Liu, Y Zhang, C Song - European Journal of Medicinal …, 2024 - Elsevier
Increasing disease-related proteins have been identified as novel therapeutic targets.
Macrocycles are emerging as potential solutions, bridging the gap between conventional …

Naringin dihydrochalcone potentially binds to catalytic domain of matrix metalloproteinase-2: molecular docking, MM-GBSA, and molecular dynamics simulation …

AK Singh, S Kumar - Natural Product Research, 2023 - Taylor & Francis
Abstract Matrix metalloproteinase-2 (MMP2), an extracellular matrix remodulating protein's
increased activity causes cancer-metastasis. Potential MMP2 inhibitors showed sever side …

[PDF][PDF] 激活素A 对乳腺癌细胞系4T1 细胞迁移及粘附影响

朱琳静, 赵云龙, 尚书米, 方芳, 汪洪宇, 邹宇佳… - 中国公共卫生, 2023 - zgggws.com
激活素A 对乳腺癌细胞系4T1 细胞迁移及粘附影响 Page 1 • 实验研究 • 激活素A 对乳腺癌细胞
系4T1 细胞迁移及粘附影响 朱琳静1,赵云龙2,尚书米1,方芳1,汪洪宇2,邹宇佳2,崔雪玲1 1. 吉林 …

Effect of activin A on migration and adhesion of breast cancer 4T1 cells

L ZHU, Y ZHAO, S SHANG, F FANG… - Chinese Journal of …, 2023 - zgggws.com
Objective To explore the effect of activin A on the migration and adhesion of murine breast
cancer 4T1 cells. Methods The viability of in vitro cultured 4T1 cells was studied using the 3 …

Meme Kanserinde MMP-2 ve MMP-9'un Rolü

T Taşkan, A Gönenç - Journal of Literature Pharmacy Sciences, 2020 - turkiyeklinikleri.com
Matriks metalloproteinaz (MMP) lar kalsiyum ve çinko bağımlı proteolitik enzim ailesidir. Bu
ailenin bir üyesi olan MMP-2 ve MMP9 jelatini, tip IV, V, VII ve X kollajeni parçalayan tip IV …