[HTML][HTML] A reflection on the improvement of Chinese hamster ovary cell-based bioprocesses through advances in proteomic techniques
M Nguyen, A Zimmer - Biotechnology Advances, 2023 - Elsevier
Chinese hamster ovary (CHO) cells are the preferred mammalian host for the large-scale
production of recombinant proteins in the biopharmaceutical industry. Research endeavors …
production of recombinant proteins in the biopharmaceutical industry. Research endeavors …
A metabolic network-based approach for developing feeding strategies for CHO cells to increase monoclonal antibody production
Chinese hamster ovary (CHO) cells are the main workhorse in the biopharmaceutical
industry for the production of recombinant proteins, such as monoclonal antibodies. To date …
industry for the production of recombinant proteins, such as monoclonal antibodies. To date …
Simultaneous monitoring of monoclonal antibody variants by strong cation-exchange chromatography hyphenated to mass spectrometry to assess quality attributes of …
F Di Marco, T Berger, W Esser-Skala, E Rapp… - International journal of …, 2021 - mdpi.com
Different manufacturing processes and storage conditions of biotherapeutics can lead to a
significant variability in drug products arising from chemical and enzymatic post-translational …
significant variability in drug products arising from chemical and enzymatic post-translational …
Nutrient supplementation strategy improves cell concentration and longevity, monoclonal antibody production and lactate metabolism of Chinese hamster ovary cells
S Pérez-Rodriguez, MJ Ramírez-Lira… - …, 2020 - Taylor & Francis
ABSTRACT A careful selection of culture mediums and feeds has become necessary to
maximize yields of recombinant proteins during bioprocesses of mammalian cells …
maximize yields of recombinant proteins during bioprocesses of mammalian cells …
[HTML][HTML] Adaptation process of engineered cell line FCHO/IL-24 stably secreted rhIL-24 in serum-free suspension culture
J Hua, Y Wei, Y Zhang, H Xu, J Ge, M Liu… - Protein Expression and …, 2022 - Elsevier
Abstract Interleukin-24 (IL-24) displays tumor cell-specific proliferation inhibition in vitro and
in vivo. Recombinant human IL-24 (rhIL-24) has significantly higher activity, yet significantly …
in vivo. Recombinant human IL-24 (rhIL-24) has significantly higher activity, yet significantly …