Lyme disease in humans

JD Radolf, K Strle, JE Lemieux, F Strle - Current issues in molecular …, 2021 - mdpi.com
Lyme disease (Lyme borreliosis) is a tick-borne, zoonosis of adults and children caused by
genospecies of the Borrelia burgdorferi sensu lato complex. The ailment, widespread …

Lyme arthritis: linking infection, inflammation and autoimmunity

RB Lochhead, K Strle, SL Arvikar, JJ Weis… - Nature Reviews …, 2021 - nature.com
Infectious agents can trigger autoimmune responses in a number of chronic inflammatory
diseases. Lyme arthritis, which is caused by the tick-transmitted spirochaete Borrelia …

Diagnosis and Treatment of Lyme Carditis: JACC Review Topic of the Week

C Yeung, A Baranchuk - Journal of the American College of Cardiology, 2019 - jacc.org
The incidence of Lyme disease, a tick-borne bacterial infection, is dramatically increasing in
North America. The diagnosis of Lyme carditis (LC), an early disseminated manifestation of …

Lyme carditis: from pathophysiology to clinical management

C Radesich, E Del Mestre, K Medo, G Vitrella, P Manca… - Pathogens, 2022 - mdpi.com
Cardiac involvement is a rare but relevant manifestation of Lyme disease that frequently
presents as atrioventricular block (AVB). Immune-mediated injury has been implicated in the …

Immune response to Borrelia: lessons from Lyme disease spirochetes

LK Bockenstedt, RM Wooten, N Baumgarth - Current issues in molecular …, 2021 - mdpi.com
The mammalian host responds to infection with Borrelia spirochetes through a highly
orchestrated immune defense involving innate and adaptive effector functions aimed toward …

[HTML][HTML] Late disseminated Lyme disease: associated pathology and spirochete persistence posttreatment in rhesus macaques

NA Crossland, X Alvarez, ME Embers - The American journal of pathology, 2018 - Elsevier
Nonhuman primates currently serve as the best experimental model for Lyme disease
because of their close genetic homology with humans and demonstration of all three phases …

A systematic review on the impact of gestational Lyme disease in humans on the fetus and newborn

LA Waddell, J Greig, LR Lindsay, AF Hinckley… - PLoS …, 2018 - journals.plos.org
Lyme disease (LD), caused by bacteria of the Borrelia burgdorferi sensu lato species
complex, is the most common vector-borne disease in North America and Europe. A …

Under-detection of Lyme disease in Canada

VK Lloyd, RG Hawkins - Healthcare, 2018 - mdpi.com
Lyme disease arises from infection with pathogenic Borrelia species. In Canada, current
case definition for confirmed Lyme disease requires serological confirmation by both a …

Cardiac Manifestations of Lyme Disease.

RV Shen, CA McCarthy - Infectious disease clinics of North America, 2022 - europepmc.org
Lyme carditis is an uncommon manifestation of Lyme disease. Most cases present with heart
block of varying degrees, but the spectrum of disease includes other transient arrhythmias …

Negative impact of the COVID-19 pandemic on the timely diagnosis of tick-borne infections

GP Wormser, E Jacobson, EM Shanker - Diagnostic Microbiology and …, 2021 - Elsevier
We describe 3 adult patients who did not have COVID-19 but instead had a treatable tick-
borne infection. In each case, however, the duration of time until diagnosis was delayed due …