HOTAIR: A key regulator of the Wnt/β-catenin signaling cascade in cancer progression and treatment
MA Hakami, A Hazazi, O Abdulaziz… - … -Research and Practice, 2024 - Elsevier
The long non-coding RNA (lncRNA) HOTAIR occupies a central position in the complex
domain of cancer biology, particularly concerning its intricate interplay with the Wnt/β …
domain of cancer biology, particularly concerning its intricate interplay with the Wnt/β …
Long non-coding RNAs as emerging targets in lung cancer
J Gencel-Augusto, W Wu, TG Bivona - Cancers, 2023 - mdpi.com
Simple Summary Long non-coding RNAs (LncRNAs) are non-protein coding molecules
longer than 200 nucleotides. They play essential roles in normal cell function and …
longer than 200 nucleotides. They play essential roles in normal cell function and …
LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell plasticity by potentiating TβRI degradation
Epithelial cells acquire mesenchymal phenotypes through epithelial‐mesenchymal
transition (EMT) during cancer progression. However, how epithelial cells retain their …
transition (EMT) during cancer progression. However, how epithelial cells retain their …
LncRNAs and PTEN/PI3K signaling: A symphony of regulation in cancer biology
WH Almalki - Pathology-Research and Practice, 2023 - Elsevier
Abstract The Emergence of Long Non-coding RNAs (lncRNAs) as Key Regulators in Diverse
Biological Processes: A Paradigm Shift in Understanding Gene Expression and its Impact on …
Biological Processes: A Paradigm Shift in Understanding Gene Expression and its Impact on …
[HTML][HTML] Approaches to probe and perturb long noncoding RNA functions in diseases
Long noncoding RNAs (lncRNAs) are a class of RNA molecules exceeding 200 nucleotides
in length that lack long open-reading frames. Transcribed predominantly by RNA …
in length that lack long open-reading frames. Transcribed predominantly by RNA …
HOTAIR in colorectal cancer: structure, function, and therapeutic potential
M Tufail - Medical Oncology, 2023 - Springer
Abstract lncRNAs play a vital part in cancer development by regulating gene expression.
Among these, the lncRNA HOTAIR has gained considerable attention due to its …
Among these, the lncRNA HOTAIR has gained considerable attention due to its …
Orthogonal inducible control of Cas13 circuits enables programmable RNA regulation in mammalian cells
RNA plays an indispensable role in mammalian cell functions. Cas13, a class of RNA-
guided ribonuclease, is a flexible tool for modifying and regulating coding and non-coding …
guided ribonuclease, is a flexible tool for modifying and regulating coding and non-coding …
Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application
Y Chen, R Liang, Y Li, L Jiang, D Ma, Q Luo… - Signal Transduction and …, 2024 - nature.com
The dynamic regulation of chromatin accessibility is one of the prominent characteristics of
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …
ST8SIA6-AS1, a novel lncRNA star in liver cancer
C Qiu, H Fan, S Tao, Z Deng, H Luo… - Frontiers in Cell and …, 2024 - frontiersin.org
Liver cancer is one of the most lethal gastrointestinal malignancies. Emerging evidence has
underscored the pivotal role of long non-coding RNAs (lncRNAs) in tumorigenesis, with …
underscored the pivotal role of long non-coding RNAs (lncRNAs) in tumorigenesis, with …
Antisense Oligonucleotide Embedded Context Responsive Nanoparticles Derived from Synthetic Ionizable Lipids for lncRNA Targeted Therapy of Breast Cancer
The long noncoding RNAs (lncRNA) are primarily associated with several essential gene
regulations but are also connected to cancer metabolism and progression. HOTAIR and …
regulations but are also connected to cancer metabolism and progression. HOTAIR and …