Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated
with proteasomes and exerts a dual function in regulating protein degradation. USP14 …

Tumors have evolved in various mechanisms to evade the immune system, hindering the
antitumor immune response and facilitating tumor progression. Immunotherapy has become …

Antimalarial drug resistance has thrown a spanner in the works of malaria elimination. New
drugs are required for ancillary support of existing malaria control efforts. Plasmodium …

The large family of deubiquitinating enzymes (DUBs) are involved in the regulation of a
plethora of processes carried out inside the cell by protein ubiquitination. Ubiquitination is a …

Human epidermal growth factor receptor 2 (HER2) is a member of epidermal growth factor
receptors with tyrosine kinase functionality. The dimerization of HER2 leads to the …

MAPK/JNK signaling is pivotal in carcinogenesis. However, ubiquitin-mediated homeostasis
of JNK remains to be verified. Here, with results from RNA sequencing (RNA-seq) and …

The ubiquitin-proteasome system (UPS) plays a central role in the degradation of cellular
proteins. Targeting protein degradation has been validated as an effective strategy for …

The BRCA1 and BRCA2 are genes that encode a protein that ensures the integrity of DNA
and prevents the unregulated cells from proliferating. Mutations in the sequence of these …

Prostate cancer (PCa) is the most common malignancy found in men and the second
leading cause of cancer-related death worldwide. Castration-resistant PCa (CRPC) is …

Allergic asthma, a chronic inflammatory illness that affects millions worldwide, has serious
economic and health consequences. Despite advances in therapy, contemporary treatments …