Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy

SD Thiberville, N Moyen, L Dupuis-Maguiraga… - Antiviral research, 2013 - Elsevier
Chikungunya virus (CHIKV) is the aetiological agent of the mosquito-borne disease
chikungunya fever, a debilitating arthritic disease that, during the past 7 years, has caused …

Chikungunya virus and prospects for a vaccine

SC Weaver, JE Osorio, JA Livengood… - Expert review of …, 2012 - Taylor & Francis
In 2004, chikungunya virus (CHIKV) re-emerged from East Africa to cause devastating
epidemics of debilitating and often chronic arthralgia that have affected millions of people in …

Vaccine and therapeutic options to control chikungunya virus

AM Powers - Clinical microbiology reviews, 2018 - Am Soc Microbiol
Beginning in 2004, chikungunya virus (CHIKV) went from an endemic pathogen limited to
Africa and Asia that caused periodic outbreaks to a global pathogen. Given that outbreaks …

Mosquito co-infection with Zika and chikungunya virus allows simultaneous transmission without affecting vector competence of Aedes aegypti

GP Göertz, CBF Vogels, C Geertsema… - PLoS neglected …, 2017 - journals.plos.org
Background Zika virus (ZIKV) and chikungunya virus (CHIKV) are highly pathogenic
arthropod-borne viruses that are currently a serious health burden in the Americas, and …

Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication

FEM Scholte, A Tas, IC Albulescu, E Žusinaite… - Journal of …, 2015 - Am Soc Microbiol
Stress granules (SGs) are protein-mRNA aggregates that are formed in response to
environmental stresses, resulting in translational inhibition. SGs are generally believed to …

Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice

D Hallengärd, M Kakoulidou, A Lulla… - Journal of …, 2014 - Am Soc Microbiol
Chikungunya virus (CHIKV) is a reemerging mosquito-borne alphavirus that has caused
severe epidemics in Africa and Asia and occasionally in Europe. As of today, there is no …

Cellular and molecular immune response to chikungunya virus infection

ISB Tanabe, ELL Tanabe, EC Santos… - Frontiers in cellular …, 2018 - frontiersin.org
Chikungunya virus (CHIKV) is a re-emergent arthropod-borne virus (arbovirus) that causes a
disease characterized primarily by fever, rash and severe persistent polyarthralgia. In the …

Recent progress in vaccine development against chikungunya virus

S Gao, S Song, L Zhang - Frontiers in microbiology, 2019 - frontiersin.org
Chikungunya fever (CHIKF) is an acute infectious disease that is mediated by the mosquito-
transmitted chikungunya virus (CHIKV). People infected with CHIKV may experience high …

Effective chikungunya virus-like particle vaccine produced in insect cells

SW Metz, J Gardner, C Geertsema, TT Le… - PLoS neglected …, 2013 - journals.plos.org
The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe
disease in humans and represents a serious public health threat in countries where Aedes …

Inhibition of dengue and chikungunya virus infections by RIG-I-mediated type I interferon-independent stimulation of the innate antiviral response

D Olagnier, FEM Scholte, C Chiang… - Journal of …, 2014 - Am Soc Microbiol
ABSTRACT RIG-I is a cytosolic sensor critically involved in the activation of the innate
immune response to RNA virus infection. In the present study, we evaluated the inhibitory …