The roles of NRF2 in modulating cellular iron homeostasis

MJ Kerins, A Ooi - Antioxidants & redox signaling, 2018 - liebertpub.com
Significance: Iron and oxygen are intimately linked: iron is an essential nutrient utilized as a
cofactor in enzymes for oxygen transport, oxidative phosphorylation, and metabolite …

The interplay between intracellular iron homeostasis and neuroinflammation in neurodegenerative diseases

J Lee, DH Hyun - Antioxidants, 2023 - mdpi.com
Iron is essential for life. Many enzymes require iron for appropriate function. However,
dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species …

[HTML][HTML] Influence of metabolism on epigenetics and disease

WG Kaelin, SL McKnight - Cell, 2013 - cell.com
Chemical modifications of histones and DNA, such as histone methylation, histone
acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of …

Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal

H Nishizawa, M Yamanaka, K Igarashi - The FEBS journal, 2023 - Wiley Online Library
Ferroptosis is triggered by a chain of intracellular labile iron‐dependent peroxidation of cell
membrane phospholipids. Ferroptosis is important not only as a cause of ischaemic and …

Iron metabolism in the CNS: implications for neurodegenerative diseases

TA Rouault - Nature Reviews Neuroscience, 2013 - nature.com
Abnormal accumulation of brain iron has been detected in various neurodegenerative
diseases, but the contribution of iron overload to pathology remains unclear. In a group of …

[HTML][HTML] The macrophage heme-heme oxygenase-1 system and its role in inflammation

V Vijayan, FA Wagener, S Immenschuh - Biochemical pharmacology, 2018 - Elsevier
Abstract Heme oxygenase (HO)-1, the inducible isoform of the heme-degrading enzyme HO,
plays a critical role in inflammation and iron homeostasis. Regulatory functions of HO-1 are …

The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce …

TS Koskenkorva-Frank, G Weiss, WH Koppenol… - Free Radical Biology …, 2013 - Elsevier
Production of minute concentrations of superoxide (O 2 radical dot−) and nitrogen monoxide
(nitric oxide, NO radical dot) plays important roles in several aspects of cellular signaling …

Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1

H Nishizawa, M Matsumoto, T Shindo… - Journal of Biological …, 2020 - ASBMB
Ferroptosis is an iron-dependent programmed cell death event, whose regulation and
physiological significance remain to be elucidated. Analyzing transcriptional responses of …

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

A Paine, B Eiz-Vesper, R Blasczyk… - Biochemical …, 2010 - Elsevier
Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-limiting enzyme of
heme degradation. Induction of HO-1 protects against the cytotoxicity of oxidative stress and …

Ferritins: a family of molecules for iron storage, antioxidation and more

P Arosio, R Ingrassia, P Cavadini - Biochimica et Biophysica Acta (BBA) …, 2009 - Elsevier
Ferritins are characterized by highly conserved three-dimensional structures similar to
spherical shells, designed to accommodate large amounts of iron in a safe, soluble and …