Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise.
In recent years, inflammatory processes have emerged as prominent contributors to the …

Background Mutations in the E3 ubiquitin ligase parkin cause autosomal recessive
Parkinson's disease (PD). Together with PTEN‐induced kinase 1 (PINK1), parkin regulates …

Parkinson's disease (PD) is a common neurodegenerative disorder that primarily affects the
elderly. While the etiology of PD is likely multifactorial with the involvement of genetic …

Understanding the complexities of the human brain and its associated disorders poses a
significant challenge in neuroscience. Traditional research methods have limitations in …

The principal hallmark of Parkinson's disease (PD) is the selective neurodegeneration of
dopaminergic neurones. Mounting evidence suggests that astrocytes may contribute to …

The mechanisms by which parkin protects the adult human brain from Parkinson disease
remain incompletely understood. We hypothesized that parkin cysteines participate in redox …

Despite the discovery of numerous molecules and pathologies, the pathophysiology of
various neurodegenerative diseases remains unknown. Genetics participates in the …

Twenty-five years have passed since the causative gene for familial Parkinson's disease
(PD), Parkin (now PRKN), was identified in 1998; PRKN is the most common causative gene …

Over the past years, brain development has been investigated in rodent models, which were
particularly relevant to establish the role of specific genes in this process. However, the …