Genetic and physiological factors affecting human milk production and composition

Y Golan, YG Assaraf - Nutrients, 2020 - mdpi.com
Human milk is considered the optimal nutrition for infants as it provides additional attributes
other than nutritional support for the infant and contributes to the mother's health as well …

Understanding the contribution of zinc transporters in the function of the early secretory pathway

T Kambe, M Matsunaga, T Takeda - International journal of molecular …, 2017 - mdpi.com
More than one-third of newly synthesized proteins are targeted to the early secretory
pathway, which is comprised of the endoplasmic reticulum (ER), Golgi apparatus, and other …

The role of the zinc transporter SLC30A2/ZnT2 in transient neonatal zinc deficiency

Y Golan, T Kambe, YG Assaraf - Metallomics, 2017 - academic.oup.com
Breast milk is the optimal nutrient mix for infants until the age of 6 months. However, in some
cases, due to genetic alterations as well as nutrient deficiencies in nursing mothers, infants …

ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion

Y Golan, R Alhadeff, A Warshel… - PLOS Computational …, 2019 - journals.plos.org
Zinc is a vital trace element crucial for the proper function of some 3,000 cellular proteins.
Specifically, zinc is essential for key physiological processes including nucleic acid …

Milk-derived miRNA profiles elucidate molecular pathways that underlie breast dysfunction in women with common genetic variants in SLC30A2

SL Kelleher, A Gagnon, OC Rivera, SD Hicks… - Scientific reports, 2019 - nature.com
Studies in humans and pre-clinical animal models show milk-derived miRNAs reflect
mammary gland function during lactation. The zinc transporter SLC30A2/ZnT2 plays a …

Zinc transporter proteins: a review and a new view from biochemistry

T Kambe, E Suzuki, T Komori - Zinc signaling, 2019 - Springer
Zinc is an essential biological metal found in approximately 10% of the human proteome.
Zinc regulates a large number of proteins and their functions, including transcription factors …

A genetic variant in SLC30A2 causes breast dysfunction during lactation by inducing ER stress, oxidative stress and epithelial barrier defects

S Lee, Y Zhou, DL Gill, SL Kelleher - Scientific reports, 2018 - nature.com
SLC30A2 encodes a zinc (Zn) transporter (ZnT2) that imports Zn into vesicles in highly-
specialized secretory cells. Numerous mutations and non-synonymous variants in ZnT2 …

[HTML][HTML] Molecular characterization of matrix metalloproteinase-1 (MMP-1) in Lucilia sericata larvae for potential therapeutic applications

H Alipour, A Raz, S Zakeri, ND Djadid - Electronic Journal of Biotechnology, 2017 - Elsevier
Background The salivary glands of Lucilia sericata are the first organs to express specific
endopeptidase enzymes. These enzymes play a central role in wound healing, and they …

Evaluation of the roles of the cytosolic N-terminus and His-rich loop of ZNT proteins using ZNT2 and ZNT3 chimeric mutants

K Fukue, N Itsumura, N Tsuji, K Nishino, M Nagao… - Scientific reports, 2018 - nature.com
The physiological roles of Zn transporter (ZNT) proteins are being increasingly recognized,
and three dimensional structures of ZNT bacterial homologs have facilitated our …

[HTML][HTML] The ins and outs of mammary gland calcium and zinc transport: A brief review

SL Kelleher - JDS communications, 2023 - Elsevier
Milk is an excellent source of all macrominerals and trace elements, which are essential for
proper function of a wide variety of vital processes. The concentrations of minerals in milk …